Mohammad Emad Azab

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Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of active methylene compounds producing pyran, pyridine and pyridazine derivatives. Also, the reactivity of the(More)
Hepatocellular carcinoma (HCC) is a deadly malignancy characterized at the epigenetic level by global DNA hypomethylation and focal hypermethylation on the promoter of tumor suppressor genes. In most cases it develops on a background of liver steatohepatitis, fibrosis, and cirrhosis. Guadecitabine (SGI-110) is a second-generation hypomethylating agent,(More)
Aberrant DNA hypermethylation favors tumor escape from host's immune recognition by decreasing the expression of tumor-associated antigens (TAA) (e.g., cancer testis antigens (CTA)), HLA, co-stimulatory molecules that are all required for efficient immune recognition of cancer cells. Thus, increased levels of DNA methylation in cancer cells might contribute(More)
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