Mohammad Afshar

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We report the design and validation of a fast empirical function for scoring RNA-ligand interactions, and describe its implementation within RiboDock, a virtual screening system for automated flexible docking. Building on well-known protein-ligand scoring function foundations, features were added to describe the interactions of common RNA-binding functional(More)
Diabetes mellitus is associated with cerebral alterations in both human and animal models of the disease. These alterations include abnormal expression of hypothalamic neuropeptides and hippocampal astrogliosis. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. The aim of this study was the evaluation of(More)
OBJECTIVE To investigate the rate of neural tube defects (NTDs) and their relation to gender, maternal age, consanguineous marriage, season, and drug consumption in Birjand, Iran. METHODS This research was carried out on 16,785 live or stillborn newborns in Birjand, Iran from April 1997 to December 2001. RESULTS The rate of NTDs was 2.97 per 1000. This(More)
— The paper attempts to give a formal framework to capture the entire process of scientific discovery including hypothesis formation, reasoning, identifying contradictions, peer reviewing, reformulating and so on. Data mining can be seen as one step in this complex process of interactive learning of an empirical theory This paper uses the terminology from(More)
To the best of our knowledge, this paper is the first attempt to for-malise a pragmatic logic of scientific discovery in a manner such that it can be realised by scientists assisted by machines. Using Institution Agents, we define a dialectic process to manage contradiction. This allows autoepistemic Institution Agents to learn from a supervised teaching(More)
BACKGROUND The molecular events, following ischemia and reperfusion (I/R) of the liver during transplantation are largely unknown. There is evidence that apoptotic and necrotic events may take place, and occasionally result in primary graft dysfunction. We herein report two cases, where significant I/R injury correlated with the development of liver(More)
OBJECTIVE To evaluate the effects of gabapentin (GBP) administration on mice fetuses. METHODS This study was carried out in Birjand University of Medical Sciences during 2008. Thirty Balb/c pregnant mice were divided randomly into 3 groups: 2 experimental groups that received 25 mg/kg (I) and 50 mg/kg (II) of GBP intraperitoneally for the first 15 days of(More)
G abapentin (GBP) (C9H17NO2), with the trade name Neurontin, is a new antiepileptic drug that was introduced by Park Davis Company in 1993 for adjunctive therapy of partial and second generalized seizures. Also, GBP was used as monotherapy in epilepsy, relief of neuropathic pain, prophylaxis of migraine, and for relief of post-dural puncture headache.(More)
BACKGROUND Hemorrhoid is one of the most common surgical diseases occurring in the anorectal region. In this study, we evaluated the effect of ischiorectal fossa block on alleviating post hemorrhoidectomy pain. METHODS In this study, 90 patients suffering from hemorrhoids were evaluated. They were randomly divided into 3 groups. The first group had no(More)