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Differential prognostic roles of Androgen Receptor (AR) have been proposed in breast cancer (BC) depending on tumour oestrogen receptor (ER) status. This study aimed to evaluate the prognostic and/or… (More)
In breast cancer (BC), the prognostic value of Ki67 expression is well-documented. Intratumoural heterogeneity (ITH) of Ki67 expression is amongst the several technical issues behind the lag of its… (More)
Centrosome aberrations (CA) and abnormal mitoses are considered beacons of malignancy. Cancer cell doubling times in patient tumors are longer than in cultures, but differences in CA between tumors… (More)
1089Background: Triple Negative Breast Cancer (TNBC) is a highly heterogeneous and aggressive breast carcinoma subtype typified by high recurrence and mortality rates. To date, no targeted therapies… (More)
© 2019 Egyptian Journal of Pathology | Published by Wo Background Clinicopathological features of basal-like breast cancer (BLBC) in African-American women have been extensively studied.… (More)
Background: Centrosome amplification (CA) which refers to presence of supernumerary or abnormally large centrosomes drives tumor progression by promoting chromosomal instability and the generation of… (More)
Background: Gene signatures including OncotypeDX are under intense study for their prognostic value, but there is also interest in their predictive value for outcome on endocrine therapy and whether… (More)
e23170Background: Centrosome amplification (CA) which refers to presence of supernumerary or abnormally large centrosomes is believed to drive tumor progression by promoting chromosomal instability...
e12560Background: HER3 must heterodimerize with EGFR in triple-negative breast cancer (TNBC) to activate the oncogenic PI3K-Akt signaling pathway. PI3K-Akt signaling is often elevated in TNBCs, but… (More)