Mohammad A. Rahman

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Based on results of simulation and empirical studies conducted within the Divisions of Biometrics, Center for Drug Evaluation and Research, Food and Drug Administration, and in collaboration with the National Toxicology Program, the Center has recently changed the significance levels for testing positive linear trend in incidence rate for common and rare(More)
  • M A Rahman
  • Journal of biopharmaceutical statistics
  • 1992
Two methods of estimating expiration date have been compared. For a drug whose potency is expected to decrease with time, method 1 fits a linear regression line to the stability data, calculates a 95% lower confidence limit of the true degradation line, and estimates the expiration date by comparing the confidence limit with the lower specification limit.(More)
For animal carcinogenicity study with multiple dose groups, positive trend test and pairwise comparisons of treated groups with control are generally performed using the Cochran-Armitage, Peto test, or Poly-K test. These tests are asymptotically normal. The exact version of CochranArmitage and Peto tests are available based on the permutation test assuming(More)
Objectives: To assess the pattern and degree of hearing loss in CSOM. Methods: A prospective study was carried out from January, 2007 to December, 2008 at the department of Otolaryngology-Head & Neck Surgery, BSMMU, Dhaka This study included 150 cases with 198 ears of CSOM including both tubo-tympanic and attico-antral variety excluding intracranial(More)
The Cochran-Armitage (CA) test is frequently used for testing the dose-response relationship in tumor incidence. This test is based on a weighted linear regression of proportions. It is well known that the CA test lacks power for nonlinear tumor outcomes. For general shape of outcomes, Hothorn and Bretz (2000) proposed a multiple contrast (MC) test. This(More)
Statistical analyses of two-year carcinogenicity data include tests for dose-response relationship (positive trend) among the increasing doses and pairwise comparisons of treated groups with control in tumor incidence by organ/tumor combination. There are two major concerns in analyzing carcinogenicity data, namely, adjustment for the difference in(More)
  • M A Rahman
  • Journal of biopharmaceutical statistics
  • 1995
Probabilities P1, P2, ..., Pn of n events E1, E2, ..., En can impose constraints on the probability of a further event E. deFinetti's fundamental theorem of probability characterizes the interval of coherent probability of E. Lad, Dickey, and Rahman (5) extended deFinetti's theorem in a few directions. In this work we will show some applications of these(More)
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