Mohamed Saad Eldin

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Miyuki Bohgaki1
Samah El Ghamrasni1
Tharan Srikumar1
1Miyuki Bohgaki
1Samah El Ghamrasni
1Tharan Srikumar
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  • Kiran Kumar Naidu Guturi, Miyuki Bohgaki, Toshiyuki Bohgaki, Tharan Srikumar, Deborah Ng, Ramya Kumareswaran +10 others
  • 2016
Topoisomerase IIα (TOP2α) is essential for chromosomal condensation and segregation, as well as genomic integrity. Here we report that RNF168, an E3 ligase mutated in the human RIDDLE syndrome, interacts with TOP2α and mediates its ubiquitylation. RNF168 deficiency impairs decatenation activity of TOP2α and promotes mitotic abnormalities and defective(More)
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