Mohamed S. Abu Nasr

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BACKGROUND AND OBJECTIVES Tuberous sclerosis complex (TSC) is a multi-systemic disorder that involves primarily CNS, skin, kidney and heart. The aim of this study is to determine whether seizures type, interictal EEGs and tubers burden in MRI are correlated to seizure and intellectual outcome, and to identify the clinical risk factors for mental retardation(More)
The objective of this study was to evaluate the influence of solid lipid nanoparticles (SLN) loaded with the poorly water-soluble drug tamoxifen citrate (TC) on the in vitro antitumor activity and bioavailability of the drug. TC-loaded SLN were prepared by solvent injection method using glycerol monostearate (GMS) or stearic acid (SA) as lipid matrix.(More)
The objective of this study was to prepare celecoxib microcrystals using different stabilizers in order to evaluate the influence of microcrystal formulation on the in vitro dissolution rate and in vivo absorption after oral administration of celecoxib in rats. Three celecoxib microcrystals (MC1, MC2, and MC3) were prepared using solvent change method.(More)
Therapies for microsporidiosis in humans are limited, and fumagillin, which appears to be the most broadly effective antimicrosporidial drug, is considered to be moderately toxic. The purpose of this study was to apply an in vitro drug screening assay for Encephalitozoon intestinalis and Vittaforma corneae and an in vivo athymic mouse model of V. corneae(More)
The objectives of this research were to prepare ribavirin niosomes and evaluate the influence of niosomal encapsulation on drug liver targeting in rats. Ribavirin niosomes were prepared by the thin film hydration method using span 60, cholesterol, and dicetyl phosphate in molar ratios of (1:1:0), (4:2:0), (1:1:0.1), and (4:2:1). The prepared niosomes were(More)
Recently, to meet higher data rate requirements, LDPC coded MIMO-OFDM systems are investigated widely. Multiple-input multiple-output (MIMO) wireless technology in combination with orthogonal frequency division multiplexing (OFDM) is an attractive solution for next-generation wireless local area networks (WLANs). Space-time block coded OFDM is capable of(More)
Wavelength converters relax the wavelength continuity constrain in wavelength routed WDM all optical networks. Since wavelength converter is an expensive component with respect to other components in optical network researches are constrained in minimizing this coast keeping the blocking performance as optimum as we can. Sparse wavelength converters,(More)
The need for flexible network structures has created a successful Wireless Local Area Network (WLAN) market, promising to replace many wired LANs in the near future. The latest draft of IEEE 802.11n offers the potential of throughputs beyond 200 Mbps, based on physical layer data rates up to 600 Mbps. IEEE 802.11n standard adopts low density parity check(More)
For a given network physical topology and traffic pattern, our objective is to design the logical topology and the routing algorithm on that topology so as to minimize the Congestion. The virtual topology design problem is a mixed integer linear formulation. Heuristic algorithms for this problem where suggested to relax MILP problem such as Heuristic(More)
Atovaquone is a chemotherapeutic agent used to treat pneumonia caused by Pneumocystis carinii in some immunocompromised patients. A set of cyclic 1,4-diones were tested in vitro for ability to inhibit growth of P. carinii, including 22 variously substituted 1,4-naphthoquinones, one bis-1,4-naphthoquinone, and three other quinones. For comparison, the(More)