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Bcr/Abl-dependent and-independent mechanisms chronic myeloid leukemia cells resistant to imatinib mesylate through both Bortezomib and Flavopiridol interact synergistically to induce apoptosis in (1930 articles) Signal Transduction (795 articles) Oncogenes and Tumor Suppressors (4217 articles) Neoplasia (231 articles) Cell Cycle (746 articles) Apoptosis(More)
Interactions between the histone deacetylase inhibitors (HDACIs) sub-eroylanilide hydroxamic acid (SAHA) and sodium butyrate (SB) and the heat shock protein (Hsp) 90 antagonist 17-allylamino-17-demethoxy-geldanamycin (17-AAG) have been examined in human leukemia cells (U937). Coadministration of marginally toxic concentrations of 17-AAG with sublethal(More)
Interactions between the proteasome inhibitor bortezomib and histone deacetylase inhibitors (HDIs) have been examined in Bcr/Abl+ human leukemia cells (K562 and LAMA 84). Coexposure of cells (24-48 hours) to minimally toxic concentrations of bortezomib + either suberoylanilide hydroxamic acid (SAHA) or sodium butyrate (SB) resulted in a striking increase in(More)
Interactions between the kinase inhibitor STI571 and pharmacological antagonists of the mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK)/mitogen-activated protein kinase (MAPK) cascade have been examined in human myeloid leukemia cells (K562 and LAMA 84) that express the Bcr-Abl kinase. Exposure of K562 cells to concentrations of(More)
The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Expression of SphK1 is up-regulated in cancers, including leukemia, and associated with cancer progression. A screen of sphingosine analogs identified (2R,3S,4E)-N-methyl-5-(4'-pentylphenyl)-2-aminopent-4-ene-1,3-diol,(More)
Interactions between pharmacologic NF-kappaB inhibitors (eg, Bay 11-7082, SN-50) and the checkpoint abrogator UCN-01 have been examined in human multiple myeloma (MM) cells. Exposure of U266 cells to Bay 11-7082 (Bay) in combination with UCN-01 resulted in the abrogation of NF-kappaB/DNA binding activity and the synergistic induction of apoptosis.(More)
In this article we present a 2D cellular automaton (Class_AC) to solve a problem of text mining in the case of unsupervised classification (clustering). Before to experiment the cellular automaton, we vectorized our data indexing textual documents from the database REUTERS 21,578 by the approach of N-grams. The cellular automaton that we propose in this(More)