Mohamed O. Buazza

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BACKGROUND Obstructive sleep apnea (OSA) is a multi-factorial and highly prevalent disorder in which both genetic and environmental factors may be involved. If left untreated, OSA may lead to significant cardiovascular and neurocognitive and behavioral morbidities. We hypothesized that pediatric OSA would lead to altered gene expression in circulating(More)
Obstructive sleep apnea (OSA) is a prevalent disorder characterized by intermittent hypoxia (IH) during sleep. OSA is strongly associated with obesity and dysregulation of metabolism—yet the molecular pathways linking the effects of IH on adipocyte biology remain unknown. We hypothesized that exposure to IH would activate distinct, time-dependent(More)
The death of retinal ganglion cells (RGCs) is the primary cause of losing vision in glaucoma, and the death of these cells may be due to the loss of neurotrophic factors. Molecular networks underlying RGCs response to serum deprivation are not fully understood. We hypothesized that there would be change in the gene expression levels associated with the(More)
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