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OBJECTIVES To assess the relationship between the presence of DHFR and DHPS mutations in Plasmodium falciparum, parasite in vitro resistance, and in vivo efficacy of sulfadoxine-pyrimethamine (SP)(More)
Many African countries currently use a sulfadoxine-pyrimethamine combination (SP) or amodiaquine (AQ) to treat uncomplicated Plasmodium falciparum malaria. Both drugs represent the last inexpensive(More)
Amodiaquine (AQ) is currently a major candidate for new antimalarial combinations, although in vivo and in vitro tests have been rarely simultaneously investigated. The efficacy of AQ was assessed at(More)
OBJECTIVES To determine the in vitro activity of antimalarial drugs against isolates of Plasmodium falciparum in Gabon. METHODS Plasmodium falciparum isolates were collected from symptomatic(More)
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