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Safety and Mechanism of Action of Orlistat (Tetrahydrolipstatin) as the First Local Antiobesity Drug
The benefits of orlistat, a new anti-obesity drug, have been assessed in this mini-review. The mechanism of action, as well as the clinical privilege of this peripheral acting drug on central actingExpand
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SYNTHESIS AND BIOLOGICAL SCREENING OF SOME NEW SUBSTITUTED-3H-QUINAZOLIN-4-ONE ANALOGS AS ANTIMICROBIAL AGENTS
-H3-  -4-   (35)  F א E א K  אאאאאאאאאא KExpand
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Glucagon-like peptide-1 derivatives and dipeptidyl peptidase-IV inhibitors. New hope for the treatment of type-2 diabetes.
Glucagon-like peptide GLP-1 is an endogenous insulinotropic/glucagonostatic hormone that acts in a self-limiting mechanism. It is a multifunctional hormone that leads to insulin release stimulation,Expand
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Synthesis and In Vitro Antioxidant Activity of some New Fused Pyridine Analogs
A new series of pyrano[3,2‐c]pyridines, pyrazolo[4,3‐c]pyridines, and pyrido[4,3‐d]pyrimidines were synthesized and screened for their in vitro antioxidant activity. Compounds 13, 14, 15, 23, 29, 30,Expand
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IN VITRO INHIBITORY EFFECT OF QUINOLINIC ACID ON ALDEHYDE OXIDASE ACTIVITY OF GUINEA PIG LIVER: A PROPOSED MECHANISM
The aim of the present study was to investigate the interaction of quinolinic acid (QA) with partially purified guinea pig liver aldehyde oxidase in terms of superoxide anion production (O2 . ),Expand
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Design, synthesis, molecular modeling and biological evaluation of novel diaryl heterocyclic analogs as potential selective cyclooxygenase-2 (COX-2) inhibitors
New series of 3,4-diaryl-2-thioxoimidazolidin-4-ones and 3-alkylthio-4,5-diaryl-4H-1,2,4-triazoles were designed, synthesized and evaluated for their activity as anti-inflammatory agents. CompoundsExpand
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ROLE OF MOLYBDENUM HYDROXYLASES IN DISEASES
The role of molybdenum-containing enzymes, aldehyde oxidase and xanthine oxidase in the production of reactive oxygen species has been discussed in term of mechanism of action. Unlike cytochrome P450Expand
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