Mohamed A. Ghoneim

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PURPOSE Previous studies demonstrate a positive correlation between postoperative survival and the extent of pelvic lymphadenectomies in patients with bladder cancer. However, the distribution of nodal metastases has not been examined in sufficient detail. Therefore, we conducted a comprehensive prospective analysis of lymph node metastases to obtain(More)
PURPOSE We performed a critical analysis of the results of radical cystectomy for invasive bladder carcinoma treated at 1 center. MATERIALS AND METHODS Between 1970 and 2000, 2,090 men and 630 women with invasive bladder cancer were treated with 1-stage radical cystectomy and urinary diversion. Followup ranged from 0 to 34.2 years with a mean of 5.5 +/-(More)
PURPOSE We report functional results of the orthotopic ileal neobladder using a serous-lined extramural tunnel as an antireflux procedure. MATERIAL AND METHODS One-stage radical cystectomy and orthotopic ileal W-shaped neobladder creation were performed in 353 male and 97 female patients for invasive bladder cancer. The ureters were reimplanted using a(More)
PURPOSE To our knowledge the extent of lymphadenectomy with cystectomy, the number of lymph nodes to be retrieved and the anatomical groups to be dissected are still undetermined. This study was done to clarify these issues. MATERIALS AND METHODS A total of 200 patients underwent radical cystectomy and extended lymphadenectomy up to the level of origin of(More)
PURPOSE We studied the factors that promote the incidence of nodal metastasis and characterized survival predictions in cases treated with radical cystectomy. MATERIALS AND METHODS We retrospectively studied 418 bladder cancer cases treated with radical cystectomy and bilateral endopelvic lymphadenectomy. The incidence of nodal involvement was correlated(More)
These studies were undertaken to determine the potential role of thromboxane receptors (TP) in bladder cancer. The data reported herein show that expression of the TP-beta receptor protein is increased in tissue obtained from patients with bladder cancer and associated with a significantly poorer prognosis (P < 0.005). Bladder cancer cell lines express the(More)
PURPOSE We evaluate the role of transforming growth factor-beta1 (TGF-beta1) in the diagnosis and followup of children with pelviureteral junction obstruction. MATERIALS AND METHODS TGF-beta1 concentration was measured in renal pelvic and bladder urine samples obtained from 15 children who underwent surgery for symptomatic unilateral pelviureteral(More)
Harvesting, expansion, and directed differentiation of human bone marrow-derived mesenchymal stem cells (BM-MSCs) could provide an autologous source of surrogate β-cells that would alleviate the limitations of availability and/or allogenic rejection following pancreatic or islet transplantation. Bone marrow cells were obtained from three adult type 2(More)
Advanced type 2 diabetes mellitus is associated with significant morbidity and mortality due to cardiovascular, nervous, and renal complications. Attempts to cure diabetes mellitus using islet transplantation have been successful in providing a source for insulin secreting cells. However, limited donors, graft rejection, the need for continued immune(More)
OBJECTIVE To study the pathophysiology of the nutcracker syndrome and to describe a new method of treatment. SUBJECTS AND METHODS Computerized tomography (CT) was used to compare the anatomical relations of the left renal vein with the aorta and the superior mesenteric artery in three patients with the nutcracker syndrome and in a control group of 12(More)