Moeen Panni

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We tested several classes of antioxidant manganese compounds for radioprotective effects using human lymphoblastoid cells: six porphyrins, three salens, and two cyclic polyamines. Radioprotection was evaluated by seven assays: XTT, annexin V and propidium iodide flow cytometry analysis, gamma-H2AX immunofluorescence, the neutral comet assay,(More)
Transection of the fimbria fornix leads to retrograde degeneration of axotomised septal cholinergic neurons as manifested by loss of choline acetyltransferase and p75NGFR immunoreactivity. Intracerebroventricularly administered nerve growth factor initiated at the time of axotomy can prevent these changes. We have shown that concurrent intraperitoneal(More)
The neurotrophins brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3) and neurotrophin 4 (NT-4), as well as their receptors, are expressed in both the developing and adult visual system. In vitro and in vivo studies suggest that BDNF in particular can enhance the survival of developing and injured retinal ganglion cells. We have previously shown(More)
Transection of the fimbria-fornix leads to retrograde degeneration of axotomized septal cholinergic neurons as manifested by loss of choline acetyltransferase and low-affinity nerve growth factor receptor (p75NGFR) immunoreactivity. Nerve growth factor administered into cerebral ventricles at the time of axotomy can prevent these changes, while ciliary(More)
Development of the visual system in Drosophila requires the establishment of precise retinotopic connections between photoreceptors and their synaptic targets in the central nervous system. Nitric oxide (NO) has been implicated as a candidate signal involved in the establishment of retinal projection patterns. In this study the expression of(More)
Developing retinal axons must follow a stereotypic course directing them to the subcortical visual centres which on arrival they must recognise. Transplantation studies suggest that local substrate cues close to the surface of the brainstem and diffusible factors emanating from the target region are important. To test a role for diffusible factors, we(More)
Preprocholecystokinin (CCK) mRNA expression was measured in a subset of hippocampal interneurones after transection of afferent septohippocampal fibres in the fimbria fornix. Two weeks after the lesions were made, CCK mRNA levels were significantly lower in these neurones on the side ipsilateral to the lesion compared with equivalent neurones on the(More)
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