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Transcriptional regulation of human polo-like kinases and early mitotic inhibitor.
Systems Biology-Based Identification of Crosstalk between E2F Transcription Factors and the Fanconi Anemia Pathway
TLDR
It is suggested that E2Fs partly determine cell fate through the FA/BRCA pathway and E2F-mediated cell cycle regulome, which is similar to the role of BRCA1 in cancer susceptibility.
Puma is a novel target of soy isoflavone genistein but is dispensable for genistein-induced cell fate determination.
TLDR
The results raise a concern that molecular targets identified by powerful omic approaches may not necessarily represent key molecules responsible for given cellular phenotypes and thus must be verified by conclusive assays.
Transcriptional Regulation of an Evolutionary Conserved Intergenic Region of CDT2-INTS7
TLDR
Real-time polymerase transcription analyses of the expression pattern for CDT2 and INTS7 mRNA in human adult and fetal tissues and cell lines revealed that transcription of these two genes are asymmetrically regulated.
FBXL16 is a novel E2F1-regulated gene commonly upregulated in p16INK4A- and p14ARF-silenced HeLa cells.
TLDR
Using a DNA microarray approach, it is shown that several genes are commonly regulated in both p16INK4A and p14ARF knockdown cells, compared with control RNA-treated cells, and RNAi-mediated knockdown of FBXL16 increased the cell proliferation rate of HeLa cells.
FBXL 16 is a novel E 2 F 1-regulated gene commonly upregulated in p 16 INK 4 Aand p 14 ARF-silenced HeLa cells
TLDR
Using a DNA microarray approach, it is shown that several genes are commonly regulated in both p16INK4A and p14ARF knockdown cells, compared with control RNA-treated cells, and RNAi-mediated knockdown of FBXL16 increased the cell proliferation rate of HeLa cells.
Expression and tissue distribution of human X-linked armadillo repeat containing-6.
TLDR
It is demonstrated that ARMCX6 tagged with green fluorescent protein was localized in the cytoplasm of HeLa cells and mRNA was highly detected in the pancreas and spleen, indicating a tissue-specific expression pattern in human tissues.