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Cardiotonic steroids are used to treat heart failure and arrhythmia and have promising anticancer effects. The prototypic cardiotonic steroid ouabain may also be a hormone that modulates epithelial cell adhesion. Cardiotonic steroids consist of a steroid nucleus and a lactone ring, and their biological effects depend on the binding to their receptor,(More)
Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though hampered by a lack of knowledge regarding the molecular mechanisms of artemisinin resistance.(More)
Dopamine (DA) is an important neurotransmitter in the Central Nervous System (CNS) of mammals being found in significant quantities in the brain. In a low concentration is associated with Parkinson's disease [1], which makes it important detection. However, a major problem in determining DA is its joint resolution with coexisting species such as ascorbic(More)
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