• Publications
  • Influence
Analysis of Assembly and Trafficking of Native P2X4 and P2X7 Receptor Complexes in Rodent Immune Cells*
P2X4 and P2X7 are the predominant P2X receptor subtypes expressed in immune cells. Having previously shown a structural and functional interaction between the two recombinant receptors, our aims hereExpand
  • 120
  • 9
Splice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1
Summary P2X7 receptors function as ATP-gated cation channels but also interact with other proteins as part of a larger signalling complex to mediate a variety of downstream responses that areExpand
  • 68
  • 2
  • PDF
Regulation of expression and trafficking of P2X4 and P2X7 receptors in immune cells
P2X4 and P2X7 are the predominant purinergic receptor subtypes expressed in macrophages, microglia and epithelial cells, and they are potentially important therapeutic targets for treatment of painExpand
Endolysosomal targeting and function of mammalian P2X4 receptors
P2X4 receptors have a widespread distribution throughout the body. In primary cells where we have examined their subcellular distribution, including macrophages, microglia and endothelial cells, theExpand
Structural and functional interaction between P2X(4), P2X(7) and pannexin-1
Activation of P2X7 receptors triggers an increase in membrane permeability to large molecules and, in immune cells, the processing and release of inflammatory cytokines. The hemi-channel Pannexin-1Expand