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Diet and Lung Cancer Risk From a 14-Year Population-Based Prospective Study in Japan: With Special Reference to Fish Consumption
It is concluded that frequent fresh fish consumption, irrespective of the cooking method, may reduce the risk of lung cancer.
Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica.
The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated and anti-cancer activity of the isolated compounds against human gastric adenocarcinoma, uterine carcinoma, and murine melanoma cells was estimated.
Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain
It is suggested that the dosing time-dependent difference in the anti-allodynic effects of gabapentin is attributable to the circadian oscillation of α2δ-1 subunit expression in the DRG and indicates that the optimizing its dosing schedule helps to achieve rational pharmacotherapy for neuropathic pain.
Effect of Haloperidol on mPer1 Gene Expression in Mouse Suprachiasmatic Nuclei*
- J. Viyoch, Naoya Matsunaga, Miyako Yoshida, H. To, S. Higuchi, S. Ohdo
- BiologyJournal of Biological Chemistry
- 25 February 2005
The results suggest that the rhythmicity of clock genes in SCN may be disturbed depending on the dosing time of Hal, and that Hal may increase CREB phosphorylation and mPer1 expression according to the activation of the NMDA receptor through the dopaminergic pathways.
A new method for evaluating the bitterness of medicines in development using a taste sensor and a disintegration testing apparatus.
- T. Harada, T. Uchida, Miyako Yoshida, Yoshikazu Kobayashi, R. Narazaki, T. Ohwaki
- BiologyChemical & pharmaceutical bulletin
- 1 August 2010
Methods for the effective utilization of a taste sensor in the development of a new medicine are described and the result shows good agreement with the results of human gustatory sensation testing, thus demonstrating the usefulness and applicability of the taste sensor and disintegration testing apparatus, ODT-101, in theDevelopment of new medicine.
Bitterness prediction of H1-antihistamines and prediction of masking effects of artificial sweeteners using an electronic tongue.
Glucocorticoid Hormone Regulates the Circadian Coordination of μ-Opioid Receptor Expression in Mouse Brainstem
It is demonstrated that the 24-h variation in circulating glucocorticoid levels modulates the analgesic effect of morphine by regulating the expression of the μ-opioid receptor.
Evaluation of palatability of 10 commercial amlodipine orally disintegrating tablets by gustatory sensation testing, OD‐mate as a new disintegration apparatus and the artificial taste sensor
- T. Uchida, Miyako Yoshida, H. Ikezaki
- BiologyThe Journal of pharmacy and pharmacology
- 1 September 2013
The purpose of this study was to evaluate and compare the palatability of 10 formulations of amlodipine orally disintegrating tablets by means of human gustatory sensation testing, disintegration/dissolution testing and the evaluation of bitterness intensity using a taste sensor.
Incompatibility of ceftriaxone sodium with calcium-containing products.
- Y. Nakai, Emi Tokuyama, Miyako Yoshida, T. Uchida
- BiologyYakugaku zasshi : Journal of the Pharmaceutical…
- 1 November 2009
Overall, not only calcium ion concentration, but storage temperature and shaking affected the extent of precipitation of ceftriaxone with calcium, and the number of microparticles in mixtures containing 1000 microg/ml ceftiaxone was significantly increased, even though concentrations of calcium ion was 1.25 mmol/l.
Comparison of the dissolution rate of ceftriaxone sodium preparations for injection.
- Mio Tange, Y. Hattori, M. Otsuka, Miyako Yoshida, J. Haginaka, T. Uchida
- Materials ScienceChemical & pharmaceutical bulletin
- 1 November 2013
The difference in dissolution time between the eight products was due to differences in powder surface characteristics, such as water interaction and crystal shape, and it was shown that the dissolution rates of the products could be predicted by NIR analysis.