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Several studies suggested that the incidence of new-onset diabetes following pediatric kidney transplantation has increased markedly in recent years, with reported incidence of up to 20%. However, limited information is available regarding the incidence and features of pretransplant status of abnormal glucose tolerance in pediatric kidney transplant(More)
Hypertension is a well-recognized complication of autosomal recessive polycystic kidney disease (ARPKD). The renin-angiotensin system (RAS) is a key regulator of blood pressure; however, data on the RAS in ARPKD are limited and conflicting, showing both up- and down-regulation. In the current study, we characterized intrarenal and systemic RAS activation in(More)
Using an absorption line from the metastable (J ; K) 1⁄4 (3; 3) level of H3 together with other lines of H3 and CO observed along several sight lines, we have discovered a vast amount of high-temperature (T 250 K) and lowdensity (n 100 cm ) gas with a large velocity dispersion in the central molecular zone (CMZ) of the Galaxy, i.e., within 200 pc of the(More)
Type Ia supernovae are thermonuclear explosions of white dwarf stars in close binary systems. They play an important role as cosmological distance indicators and have led to the discovery of the accelerated expansion of the Universe. Among the most important unsolved questions about supernovae are how the explosion actually proceeds and whether accretion(More)
Plasma hyperhomocysteinemia (HHcy) is considered a risk factor for chronic allograft dysfunction (CAD), the main cause of functional loss in transplant recipients. Genetic polymorphisms that alter enzymes involved in homocysteine (Hcy) metabolism, such as methylenetetrahydrofolate reductase (MTHFR), and vitamin deficiency can result in HHcy. The objectives(More)
We have investigated the optical and near-infrared colors of K -selected galaxies in clusters at z ∼ 1.2 near to the radio galaxy 3C 324 using images obtained with the Subaru telescope and archival HST data. The distribution of colors of the galaxies in the cluster region is found to be fairly broad, and it may imply significant scatter in their(More)
BACKGROUND Long-term therapy of mizoribine (MZR 2-5 mg/kg/day) has been reported in the management of children with frequently relapsing nephrotic syndrome(FRNS). It had minimum adverse effects, however, MZR therapy does not sufficiently suppress the relapse of FRNS. Previous reports suggested that modification of MZR therapy with a total dosage and(More)
OBJECTIVES Congenital hepatic fibrosis (CHF) is an important cause of morbidity and mortality in patients with autosomal recessive polycystic kidney disease (ARPKD). The pathogenesis of CHF remains undefined. Several recent studies suggest that the renin-angiotensin system (RAS) is an important mediator of progressive hepatic fibrosis through activation of(More)
Infrared absorption lines of H3 , including the metastable R(3,3) l line, have been observed toward eight bright infrared sources associated with hot and massive stars located in and between the Galactic Center Cluster and the Quintuplet Cluster 30 pc to the east. The absorption lines with high velocity dispersion arise in the Galaxy’s Central Molecular(More)
Cassiopeia A is the youngest supernova remnant known in the Milky Way and a unique laboratory for supernova physics. We present an optical spectrum of the Cassiopeia A supernova near maximum brightness, obtained from observations of a scattered light echo more than three centuries after the direct light of the explosion swept past Earth. The spectrum shows(More)