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We have developed a new quantitative method to determine protein concentration and number of cells in the aqueous in vivo. The principal instruments in the system were a He-Ne laser and a detection system for measuring scattered light intensity. The power of the He-Ne laser was 25 microW and the focused beam diameter was 20 microns. The laser beam was(More)
PURPOSE To elucidate tumor necrosis factor (TNF) receptor-1 (TNFR1) and TNF-alpha converting enzyme (TACE) involvement during corneal wound healing. METHODS The corneas of BALB/c mice cornea were scarred by alkali burns using filter paper dipped in 1N NaOH solution. TACE and TNFR1 expression in the alkali-burned corneas were evaluated by(More)
PURPOSE To investigate differences in the cytokine and chemokine profiles of patients with vernal keratoconjunctivitis (VKC) or giant papillary conjunctivitis (GPC). METHODS The study included six patients (six eyes) with VKC, five patients (five eyes) with GPC, and five healthy volunteers (five eyes) as controls. None of the patients had received any(More)
  • M Sawa
  • 1990
Clinical application of the laser flare-cell meter was described. The instrument was developed for concurrent quantitative determinations of the flare and number of cells in the aqueous humor. Diurnal variations were demonstrated in the aqueous flare, and also an increase in the flare with increasing age. The effects of drugs on aqueous humor dynamics were(More)
PURPOSE To survey the changes in indications for penetrating keratoplasty (PKP) and re-evaluate the risk factors for allograft rejection and graft failure. METHODS We evaluated the records of 396 eyes of 335 patients who had undergone PKP at the Tokyo University Hospital between 1987 and 1997. Clinical results were analyzed by the Kaplan-Meier life table(More)
AIMS To clarify the cerebellar control of accommodation in humans, the frequency characteristics of accommodation were studied in a patient with agenesis of the posterior cerebellar vermis and four age matched normal subjects. METHODS Magnetic resonance imaging of the brain of the 29 year old patient showed agenesis of the vermis and paravermis of lobules(More)
We performed an immunohistochemical study of follicular dendritic cells (FDC) in the follicular area of the conjunctiva-associated lymphoid tissue (CALT). Hartley guinea pigs were sensitized with a topical application of an emulsion of ovalbumin and Freund's complete adjuvant in the eye. They were divided into four groups. The control (group A) underwent no(More)
High endothelial venule (HEV) is an important component of the mucosa-associated lymphoid tissue and plays a role in the homing phenomenon of lymphocytes. We investigated the presence of HEVs in conjunctiva-associated lymphoid tissue (CALT) using guinea pigs sensitized with ovalbumin. Electron microscopy showed characteristic findings for HEVs in the(More)
We compared the distribution of S-100 protein positive cells in normal conjunctiva and in an induced allergic conjunctivitis model using Hartley strain guinea pigs. The animals were sensitized by intraperitoneal injection of ovoalbumin solution with hydroxy aluminum, followed by topical application of the ovoalbumin solution. The primary antibody was(More)