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The mechanisms that lead from obesity to atherosclerotic disease are not fully understood. Obesity involves angiogenesis in which vascular endothelial growth factor-A (VEGF-A) plays a key role. On the other hand, vascular endothelial growth factor-C (VEGF-C) plays a pivotal role in lymphangiogenesis. Circulating levels of VEGF-A and VEGF-C are elevated in(More)
Intracellular calcium is one of the important signals that initiates the myogenic program. The calcium-activated phosphatase calcineurin is necessary for the nuclear import of the nuclear factor of activated T cell (NFAT) family members, which interact with zinc finger GATA transcription factors. Whereas GATA-6 plays a role in the maintenance of the(More)
The present study was aimed at clarifying the effects of vibration syndrome (VS) on the distal part of the radial nerve, which is rarely affected by chronic entrapment. Thirty-one patients with VS due to previous exposure to vibration and 18 age-matched controls were examined for sensory nerve conduction velocities in the distal part of the radial nerve(More)
Autonomic nervous function in response to cold was investigated in 21 patients with vibration-induced white finger (VWF) and 17 healthy controls of similar age, using power spectral analysis of heart rate variability. In a supine position, electrocardiogram and skin temperature of both index fingers were measured during immersion of right hand in cold water(More)
We propose a new method for controlling multiagent systems proactively considering the gcontrol possibility h and gcontrol effect h for reducing the decrement of QoS to the absolute minimum while providing service in a service-provisioning system based on multiagent system. Moreover, we implement a multimedia communication system based on the proposed(More)
BACKGROUND Atrial fibrillation (AF) increases the risk of stroke and death. Data on the predictors for stroke and death in 'real-world' AF patients are limited, especially from large prospective Asian cohorts. METHODS The Fushimi AF Registry is a community-based prospective survey designed to enroll all AF patients who visited the participating medical(More)
There has been no previous prospective study evaluating dual antiplatelet therapy (DAPT) duration shorter than 6 months after cobalt-chromium everolimus-eluting stent (CoCr-EES) implantation. STOPDAPT trial is a prospective multi-center single-arm study evaluating 3-month DAPT duration after CoCr-EES implantation. The primary endpoint was a composite of(More)
A trial fibrillation (AF) is a global problem with a significant impact on health outcomes, affecting up to 1% to 2% of the global adult population, and is projected to increase in both developed and developing countries over the coming decades. 1 AF is associated with higher mortality and morbidity , as well as decreased quality of life, and increases the(More)
Controversy exists regarding whether left atrial enlargement (LAE) is a predictor of stroke/systemic embolism (SE) in atrial fibrillation (AF) patients. The Fushimi AF Registry, a community-based prospective survey, enrolled all AF patients in Fushmi-ku, Japan, from March 2011. Follow-up data and baseline echocardiographic data were available for 2,713(More)
Relation of antiplatelet therapy (APT) discontinuation with the risk of serious cardiovascular events has not been fully addressed yet. This study is aimed to evaluate the risk of ischemic event after APT discontinuation based on long-term APT status of large cohort. In the CREDO-Kyoto Registry Cohort-2 enrolling 15939 consecutive patients undergoing first(More)