Mitsuo Tonoike

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1. Odor responses to two homologous series of n-fatty acids (nFA) and n-aliphatic alcohols (nAA) with a straight chain of three to nine carbons were examined by measuring odor-induced [Ca2+]i increase in mouse olfactory receptor neurons (ORNs) isolated by the tissue-printing method. 2. One-third of the ORNs responsive to nFA and/or nAA were alternately(More)
Ultrasound can be perceived through bone conduction by the profoundly deaf as well as by normal-hearing subjects. Moreover, speech signals modulated onto ultrasound can be detected through bone conduction. This study explored how well listeners can understand ultrasonic speech and the confusion patterns to evaluate and improve bone-conducted ultrasonic(More)
Olfactory transduction involves second messenger-related enzymes and cAMP-gated, K+ and Ca2+ channels, which are known to be regulated by Ca2+. We report here that cytosolic free Ca2+ concentration ([Ca2+]i) in olfactory receptor neuron was increased by odorants or forskolin and Ca2+ influx contributed to the adaptation. The increases in [Ca2+]i were below(More)
Auditory evoked magnetic fields in relation to iterated rippled noise (IRN) were examined by magnetoencephalography (MEG). IRN was used as the sound stimulus to control the peak amplitude of the autocorrelation function of the sound. The IRN was produced by a delay-and-add algorithm applied to bandpass noise that was filtered using fourth-order Butterworth(More)
A new method is described for isolating olfactory receptor neurons suitable for simultaneous recording of odorant responses in several cells. This method, called "tissue printing" by Cassab and Varner, was used to isolate cells for measurement of odorant-induced increases in cytosolic-free calcium concentration ([Ca2+]i) using the Ca2+ indicator dye fura-2.(More)
The effect of frequency on N1m has been investigated by various methods. However, it has not yet been measured using forward masking. In this study, the frequency specificity of N1m was investigated using forward masking. Although the masker frequency had some influence on N1m amplitudes, the results suggested that the frequency specificity of N1m was worse(More)
Auditory sensation is affected by a forward masker, and this phenomenon has been demonstrated in a neural adaptation model and a temporal window (integration) model. To study forward masking in the central auditory system, the growth of the N1m amplitude was measured by varying the signal delay. In the adaptation model, the masking increases as the signal(More)
 The phase-resetting experiment was applied to human periodic finger tapping to understand how its rhythm is controlled by the internal neural clock that is assumed to exist. In the experiment, the right periodic tapping movement was disturbed transiently by a series of left finger taps in response to impulsive auditory cues presented randomly at various(More)
Ninety-nine single neuron activities of the dorsolateral prefrontal cortex of 3 monkeys were recorded during performance of a Konorski task. Green or red lights were presented successively with a separation of fixed delay interval. The monkey responded as soon as the second stimulus was presented. If the two stimuli were color-matched, the 'YES' lever press(More)
Sound duration conveys phonemic information in some languages. The present study, using magnetoencephalography (MEG), examined whether the hemispheric activation associated with the processing of duration is different between speech and non-speech sounds in subjects whose native language uses duration as a phonemic cue. The magnetic mismatch negativity(More)