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Involvement of an Autocrine Stromal Cell–Derived Factor-1/CXCR4 System on the Distant Metastasis of Human Oral Squamous Cell Carcinoma
TLDR
Under the present conditions, AMD3100, a CXCR4 antagonist, significantly inhibited the lung metastasis of the SDF-1 transfectant, ameliorated body weight loss, and improved the survival rate of tumor-bearing nude mice. Expand
Expression of Toll-Like Receptor 4 on Dendritic Cells Is Significant for Anticancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432, a Streptococcal
TLDR
It is suggested that OK-PSA may be a potent adjuvant for local DC therapy, and that DC therapy followed by OK- PSA is able to elicit anticancer activity even in aTLR4-deficient host when TLR4 is expressed only in DCs injected intratumorally. Expand
Mechanism of Anticancer Host Response Induced by OK-432, a Streptococcal Preparation, Mediated by Phagocytosis and Toll-Like Receptor 4 Signaling
TLDR
In in vivo experiments, the anticancer effect of OK-432 was significantly inhibited by suppression of phagocytosis activity by cytochalasin B, and in vitro experiments elucidated the mechanism mediated by phagocytes and TLR4 signaling in the immune effect ofOK-432. Expand
The clinicopathological significance of the expression of CXCR4 protein in oral squamous cell carcinoma.
TLDR
Results indicate that SDF-1/CXCR4 signaling in oral S CC cells might be involved in the diverse action of oral SCC, including invasion or micrometastasis at the primary site and lymph node metastasis. Expand
Mechanism for bone invasion of oral cancer cells mediated by interleukin‐6 in vitro and in vivo
TLDR
Although interleukin (IL)‐6 accelerates osteoclastic bone resorption, it remains unclear whether IL‐6 may be involved in bone invasion of oral cancer. Expand
Involvement of Toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432.
TLDR
TLR4 and MD-2 may mediate OK-432-induced anticancer immunity and be associated with the in vivo IFN-gamma induction in 19 patients administeredOK-432. Expand
Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma
TLDR
Results indicate that SDF-1/CXCR4 signaling mediates the establishment of lymph node metastasis in oral SCC via ERK1/2 or Akt/PKB pathway. Expand
Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells.
TLDR
Results suggested that EMT induced by the SDF-1/CXCR4 system might be involved in the lymph node metastasis of oral SCCs via activation of PI3K-Akt/PKB pathway. Expand
Toll-like receptor signaling in anti-cancer immunity.
TLDR
It is demonstrated that TLR4 signaling is intimately involved in anti-cancer immunity induced by these immunopotentiators, and the clinical examination in oral cancer patients also suggests the requirement of bothTLR4 and MD-2 in the OK-432-induced anti- cancer host response. Expand
Biological effect of OK-432 (picibanil) and possible application to dendritic cell therapy.
TLDR
Results suggest that OK-432 is a useful adjuvant in DC-based anticancer immunotherapy, and dendritic cells are considered to play a pivotal role in immunological response. Expand
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