Mitsuko Kawano

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T helper 17 cells, characterized by interleukin-17 (IL-17) production, play a critical role in the pathogenesis of autoimmune disease, including alopecia areata (AA). In this report, we employed immunohistochemical staining for IL-17-producing cells, as well as interferon-γ-producing cells, granulysin-bearing cells and Foxp3+ regulatory T cells, and(More)
Natural killer (NK) cells contribute to not only innate but also to adaptive immunity by interacting with dendritic cells (DCs) and T cells. All activated human NK cells express HLA-DR and can initiate MHCII-dependent CD4(+) T-cell proliferation; however, the expression of MHCII by mouse NK cells and its functional significance are controversial. In this(More)
The natural killer group 2 membrane D (NKG2D) activating receptor plays crucial roles not only in host defense against tumors and viral infections, but also in autoimmune diseases. After NKG2D-mediated activation, Natural killer (NK) cells must be regulated to avoid potentially harmful reactivity. However, the negative regulation of these activated NK cells(More)
Metal allergy is categorized as a delayed-type hypersensitivity reaction, and is characterized by the recruitment of lymphocytes into sites of allergic inflammation. Because of the unavailability of suitable animal models for metal allergy, the role of T cells in the pathogenesis of metal allergy has not been explored. Thus, we developed a novel mouse model(More)
© 2014 The Authors. doi: 10.2340/00015555-1807 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Langerhans cell histiocytosis (LCH) is characterised by the clonal proliferation of Langerhans cells (LC) that predominantly occurs in infants and small children, but LCH is rare in adults (1). Generally in children, local therapy would be an(More)
Nickel, cobalt, and chromium are well known to be causal agents of allergic contact dermatitis. Palladium (Pd) can also cause allergic disease and exposure results from wide use of this metal in dental restorations and jewelry. Metal allergy is categorized as a delayed-type hypersensitivity, and metal-responsive T cell clones have been isolated from(More)
CD30+ lymphoproliferative disorders represent a spectrum of diseases from lymphomatoid papulosis (LyP) to primary cutaneous anaplastic large-cell lymphoma (PCALCL) (1, 2). LyP is characterized by recurrent papulonodular lesions, which undergo spontaneous regression (1, 2). Survival is unaffected by LyP, but patients are at risk of a second cutaneous or(More)
The immune system can operate a multipronged control on tumor progression, implying that malignant cells must develop multiple immunoregulatory strategies to evade antitumor immune responses. An improved understanding of the complex interplay between malignant cells and immune cells is therefore crucial for development of effective anticancer(More)
Nickel (Ni) eluted from metallic biomaterials is widely accepted as a major cause of allergies and inflammation. To improve the safety of cobalt-chromium-molybdenum (Co-Cr-Mo) alloy implants, new ultralow-Ni Co-Cr-Mo alloys with and without zirconium (Zr) have been developed, with Ni contents of less than 0.01%. In the present study, we investigated the(More)
Two-step thermal oxidation was proposed for Ti and Ti alloys as a surface-treatment process for preparing an anatase-containing TiO2 layer. This process consisted of treatment in a CO-containing atmosphere (first step) and subsequent treatment in air (second step). In this chapter, first, the current status of TiO2 coating onto Ti and Ti alloys for(More)