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Dysfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis
TLDR
ENOS may have 2 faces in the pathophysiology of atherosclerosis depending on tissue BH4 metabolisms, and overexpression with hypercholesterolemia may promote atherogenesis via increased superoxide generation from dysfunctional eNOS.
Superoxide Generation in Directional Coronary Atherectomy Specimens of Patients With Angina Pectoris
TLDR
ROS were closely associated with the distribution of p22phox and oxidized LDL and the generation of superoxide in DCA specimens was assessed by the dihydroethidium method and lucigenin-enhanced chemiluminescence.
HMG-CoA Reductase Inhibitor Has Protective Effects Against Stroke Events in Stroke-Prone Spontaneously Hypertensive Rats
TLDR
The purpose of this study is to clarify the effect of a statin on stroke in stroke-prone spontaneously hypertensive rats (SHR-SP), in which both cerebral hemorrhage and infarction occur.
Serotonin-Induced Hypercontraction Through 5-Hydroxytryptamine 1B Receptors in Atherosclerotic Rabbit Coronary Arteries
TLDR
Serotonin-evoked contractions in both groups were inhibited by GR127935 and pertussis toxin but not by ketanserin (5-HT2 antagonist), suggesting that the hypercontraction is most likely ...
Adrenomedullin Augments Inducible Nitric Oxide Synthase Expression in Cytokine-Stimulated Cardiac Myocytes
TLDR
The adrenomedullin-induced nitrite production by interleukin-1β–stimulated cells was accompanied by increased inducible NO synthase mRNA and protein expression, which resulted in a significant increase in nitrite accumulation.
Nitric Oxide Spares Myocardial Oxygen Consumption Through Attenuation of Contractile Response to β-Adrenergic Stimulation in Patients With Idiopathic Dilated Cardiomyopathy
TLDR
The aim of the present study was to address the role of NO in left ventricular (LV) contractile response to β-adrenergic stimulation and corresponding oxygen expenditure in human heart failure.
Interaction of Oxidative Stress and Inflammatory Response in Coronary Plaque Instability
TLDR
Characteristics of histological plaque instability and higher levels of serum CRP and fibrinogen were associated with the CRP immunoreactivity and the expression of CRP mRNA and protein was detected in cultured human coronary artery smooth muscle cells.
Possible Role of Brain-Derived Neurotrophic Factor in the Pathogenesis of Coronary Artery Disease
TLDR
The difference in BDNF levels, but not NT-3, between the coronary sinus and aorta was significantly greater in the unstable angina group compared with the stable effort angina and non–coronary artery diseas...
Taurine Prevents the Decrease in Expression and Secretion of Extracellular Superoxide Dismutase Induced by Homocysteine
TLDR
Whether homocysteine and taurine affect the expression and secretion of extracellular superoxide dismutase (EC-SOD), a glycoprotein secreted from vascular smooth muscle cells (VSMCs) that protects the vascular wall from oxidative stress is examined.
Involvement of Endothelial Nitric Oxide in Sphingosine-1-Phosphate–Induced Angiogenesis
TLDR
S1P increased capillary ingrowth into subcutaneously implanted Matrigel plugs in mice, and the effect of S1P was significantly reduced in mice that received NG-nitro- l-arginine methyl ester (l-NAME), an inhibitor of NOS.
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