Mitsuhiro Omine

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Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes, but also with gain-of-function mutations of proto-oncogenes. Here we show unique gain-of-function mutations of the C-CBL (also known as CBL) tumour suppressor(More)
Patients with a myelodysplastic syndrome (MDS) which has a risk of leukaemic change exhibit a variable clinical course. It has been suggested that the development of leukaemia in patients with MDS may be related to chromosomal abnormalities or genetic alterations: somatic mutation of the N-ras gene is now considered to be a critical step in the genetic(More)
SUMMARY In AKR mice that develop spontaneous lymphoid leuke mia, the thymus is the organ of primary involvement. Thy-mic cells from normal mice, as well as from mice with ad vanced leukemia, were separated according to size by sedimentation in a l x g sucrose gradient, the larger cells sedimenting further than the smaller cells. The fractions obtained from(More)
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