Mitsuhiro Omine

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Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes, but also with gain-of-function mutations of proto-oncogenes. Here we show unique gain-of-function mutations of the C-CBL (also known as CBL) tumour suppressor(More)
SUMMARY In AKR mice that develop spontaneous lymphoid leuke mia, the thymus is the organ of primary involvement. Thy-mic cells from normal mice, as well as from mice with ad vanced leukemia, were separated according to size by sedimentation in a l x g sucrose gradient, the larger cells sedimenting further than the smaller cells. The fractions obtained from(More)
Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity (LOH). aUPD is associated not only with loss-of-function mutations of tumor suppressor genes 1 but also with gain-of-function mutations of proto-oncogenes 2. Here we show unique gain-of-function mutations of C-CBL (also known as CBL) tumor suppressor(More)
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