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Journals and Conferences
The dynamic and mechanical properties of mammalian neural microtubules have been widely studied; however, similar knowledge about these properties is limited for non-neural microtubules, which, unlike neural microtubules, consist of different β-tubulin isotypes. In this study, we report, for the first time, an estimated value for the persistence length of a… (More)
While there have been many single-molecule studies of kinesin-1, most have been done along microtubules purified from bovine or porcine brain, and relatively little is known about how variations in tubulin might alter motor function. Of particular interest is transport along microtubules polymerized from tubulin purified from MCF7 breast cancer cells, both… (More)
By combining the total cell evolution curve and a two-compartmentmodel interactingwith dynamic anti-cancer agents, the evolution of subpopulations has been analytically obtained and investigated in this work. © 2009 Elsevier Ltd. All rights reserved.
In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotherapeutic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then add the… (More)
In this short work, by combining the total cell evolution curve and the two-compartment model, the evolution of one of the subpopulations is simulated while the system interacts with a proliferating regulatory factor. © 2009 Elsevier Ltd. All rights reserved.
In this paper, we modify our previously developed conjoint tumor-normal cell model in order to make a distinction between tumor cells that are responsive to chemotherapy and those that may show resistance. Using this newly developed core model, the evolution of three cell types: normal, tumor, and drug-resistant tumor cells, is studied through a series of… (More)
The extent to which beta tubulin isotypes contribute to the function of microtubules and the microtubule-driven transport of molecular motors is poorly understood. The major differences in these isotypes are associated with the structure of their C-terminal tails. Recent studies have revealed a few aspects of the C-terminal tails’ regulatory role on the… (More)
Dynamic instability describes microtubule assembly in which individual microtubules exhibit alternating phases of elongation and rapid shortening. This dynamic is significantly different for the plus ends and minus ends of a microtubule. In this work, by considering the contribution of the plus and minus ends, we have investigated the behavior of T-tubulin… (More)
There is known to be significant diversity of β-tubulin isoforms in cells. However, whether the functions of microtubules that are polymerized from different distributions of beta isotypes become distinct from one another are still being explored. Of particular interest, recent studies have identified the role that different beta tubulin isotypes carry in… (More)
The kinesin 5 motor contributes critically to mitosis, and is often upregulated in cancer. In vitro motility studies of kinesin 5 moving along bovine brain microtubules indicate that the motors have limited processivity. Cancer cells have abnormal mitotic behavior, so one might wonder whether the functional properties of kinesin 5 change in such a… (More)