Mitja Mitrovic

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Targeted sequencing of sixteen SLE risk loci among 1349 Caucasian cases and controls produced a comprehensive dataset of the variations causing susceptibility to systemic lupus erythematosus (SLE). Two independent disease association signals in the HLA-D region identified two regulatory regions containing 3562 polymorphisms that modified thirty-seven(More)
The transcription factor nuclear factor κB (NFκB) is a central regulator of inflammation, and genome-wide association studies in subjects with autoimmune disease have identified a number of variants within the NFκB signaling cascade. In addition, causal variant fine-mapping has demonstrated that autoimmune disease susceptibility variants for multiple(More)
Foxp3(+) regulatory T cells (Tregs) exhibit plasticity, which dictates their function. Secretion of the inflammatory cytokine IFNγ, together with the acquisition of a T helper 1 (Th1)-like effector phenotype as observed in cancer, infection, and autoimmune diseases, is associated with loss of Treg suppressor function through an unknown mechanism. Here, we(More)
Die Wirkung von vier faszioliziden Agentien (Rafoxanid, Oxyklozanid, Nitroxynil und Diamphenethid) wurde im Mäuseversuch verglichen. Alle vier Substanzen waren gegen unreifeFasciola hepatica wirksam und entfalteten ihre höchste Wirksamkeit gegen spätere unreife Stadien, mit Ausnahme von Diamphenethid, welches gegen die Frühstadien der unreifen Parasiten am(More)
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