Mithun Jacob Varghese

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Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism resulting in elevated serum low-density lipoprotein (LDL) cholesterol levels leading to increased risk for premature cardiovascular diseases (CVDs). The diagnosis of this condition is based on clinical features, family history, and elevated LDL-cholesterol levels aided more(More)
Diphtheria continues to be reported from many parts of the world. Complete heart block is rare but often fatal complication of diphtheric myocarditis. We report six children with diphtheric myocarditis who presented with complete heart block. Three patients survived, one with persistent complete heart block. Aggressive supportive management including(More)
PURPOSE To describe a precannulated fenestrated endograft system utilizing externalized guidewires to facilitate aortic arch endovascular repair and to report its use in 2 patients with challenging anatomy. TECHNIQUE For distal arch repair, a fenestration for the left subclavian artery (LSA) is made onsite in a standard thoracic endograft tailored to the(More)
OBJECTIVE Obstructive sleep apnea (OSA) is a prevalent condition that is increasingly recognized to be associated with cardiovascular disease. We aimed to investigate the subclinical systolic ventricular dysfunction of patients with OSA using novel speckle tracking echocardiographic (STE) techniques. METHODS This study included 31 patients of(More)
Stavrou K, Migliorini A, Antoniucci D, Tamburino C, Alexopoulos D. Morphine is associated with a delayed activity of oral antiplatelet agents in patients with ST-elevation acute myocardial infarction undergoing primary percutaneous coronary intervention. Circ Cardiovasc Interv 2015;8:e001593. 12. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR,(More)
Neurological manifestations such as seizures although rare are well recognized presentations of cardiac arrhythmias. Almost always, such events are primarily generalized in nature leading on to loss of consciousness. Rarely however, cardiac seizures can manifest with focal neurological events. We report a case of a sexagenarian who presented with recurrent(More)
A direct right pulmonary artery to left atrial fistula is a rare congenital condition in which patients usually present with isolated cyanosis in the absence of abnormal cardiovascular findings. We report the percutaneous closure of such a defect in a young woman who presented with severe cyanosis. This was achieved without making a conventional venovenous(More)
38-year-old woman presented with features of gradually progressive right heart failure Aover 20 years with recent exacerbation of symptoms. She had undergone implantation of an epicardial pacemaker for symptomatic sinus bradycardia 10 years previously; however, she was noted to be in atrial fibrillation with rapid ventricular rate at the present hospital(More)
A 52-year-old lady presented with progressive exertional breathlessness and palpitation of 3 years duration. She reported history suggestive of acute rheumatic fever at the age of 18 years, but was not on regular penicillin prophylaxis. Cardiovascular examination showed features of atrial fibrillation with long mid-diastolic rumble at the apex indicative of(More)