Mithilesh Sharma

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Lymphatic filariasis continues to be a major health problem in tropical and subtropical countries. A macrofilaricidal agent capable of eliminating adult filarial parasites is urgently needed. In the present study, we report the antifilarial activity in the extract of stem portion of the plant Lantana camara. The crude extract at 1 g/kg for 5 days by oral(More)
Parkinson's disease is caused by a complex interplay of genetic and environmental factors. Although a number of independent molecular pathways and processes have been associated with familial Parkinson's disease, a common mechanism underlying especially sporadic Parkinson's disease is still largely unknown. In order to gain further insight into the etiology(More)
Background: A triplication of the α-synuclein gene was found to cause autosomal dominant Lewy body disease in two distinct families. Method: We searched for alterations of α-synuclein gene dosage and analysed the entire coding region for point mutations in 54 dementia with Lewy body disease (DLB) and in 103 young onset Parkinson’s disease (PD) patients from(More)
Present study has shown that differentiated cell types may loose their definitive characteristics and acquire features of another specialized cell type. Young (3 toe stage) and mature (5 toe stage) tadpoles of the frog, Euphylictis cyanophlyctis were employed as experimental animals. Experiments were completed in two phases: in the first part of experiment,(More)
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