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Evidence That Members of the TGFβ Superfamily Play a Role in Regulation of the GnRH Neuroendocrine Axis: Expression of a Type I Serine‐Threonine Kinase Receptor for TGRβ and Activin in GnRH Neurones…
Dual‐label in situ hybridization histochemistry showed that 31±5% of GnRH neurones expressed B1 mRNA, thus providing evidence that TGFβ and/or activin can act directly on Gn RH neurones to modulate their activity.
Evidence for Expression of Galanin Receptor Gal‐R1 mRNA in Certain Gonadotropin Releasing Hormone Neurones of the Rostral Preoptic Area
The results suggest that, in addition to a possible indirect action of galanin on GnRH cells via neurones located at close proximity, the effects of Galanin can be mediated by direct activation of galansin receptors in rostral GnRH neurones.
Adhesion Receptor Activation of Phosphatidylinositol 3-Kinase
The results suggest that vWF binding to the platelet adhesion receptor glycoprotein Ib/M can mediate activation and translocation of both tyrosine and lipid kinase(s) independent of other agonists.
Diagnostic Detection of Herpes Simplex and Hepatitis C Viral Amplicons by Capillary Electrophoresis: Comparison With Southern Blot Detection.
Towards a carbohydrate-based vaccine against leishmaniasis
Leishmania major infection of mice produces a range of disease patterns, similar to the situation in man, depending on the strain of inbred mouse, but hypothymic nude mice of both resistant and susceptible genotypes are highly susceptible, suggesting a role for T cell-dependent immunity in resistance to disease.
Characterization of the Mr 65,000 Lymphokine-activated Killer Proteins Phosphorylated after Tumor Target Binding: Evidence That pp65a and pp65b Are Phosphorylated Forms of as2
It is hypothesized that p65 phosphorylation in LAKS may regulate adhesion to tumor targets and a possible role for pp65a and pp6sb in LAK-mediated cytotoxicity can be postulated based on the known properties of plastins.
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Two distinct regions of the large serine recombinase TnpX are required for DNA binding and biological function, and recommendations for the nomenclature of receptors for relaxin family peptides are made.
Exon S Deletion Variant Estrogen Receptor Messenger RNA Expression in Relation to Tamoxifen Resistance and Progesterone Receptor / pS 2 Status in Human Breast Cancer '
Genes Are Mediated by Protein Kinase CHa ras Activated Alterations in Murine Keratinocyte Differentiation Induced by Updated Version
The results of this study suggest that oncogenic ras alters kern tinocyte differentiation by altering the function of the PKC signaling pathway, and that PKC-a Is the specific isozyme involved in down modulating expression of keratins K! and K1O and up-regulating expres sion of loricrin, filaggrin, and keratinocyte transglutaminase.
The Role of Type I and Type II Tumor Necrosis Factor Receptors the Ability of TNF-a to Transduce a Proliferati ve Signal in the Human Megakaryoblastic Leukemic Cell Line Mole1
The data suggest that an alternative signaling pathway may be involved in TNF-a-induced Mo7e cell prolif eration, because the common mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) signaling pathways activated by other cytokines that induce Mo 7e cell proliferation are not activated by TNF -a.