Mitchell S Rothman

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Phospholamban is a 52 amino acid residue membrane protein involved with the regulation of calcium levels across sarcoplasmic reticulum membranes in cardiac muscle cells. The N-terminal 30 amino acid residues of the protein are largely hydrophilic and include two sites whose phosphorylation is thought to dissociate an inhibitory complex between phospholamban(More)
Phospholamban is a 52-amino acid residue membrane protein that regulates Ca(2+)-ATPase activity in the sarcoplasmic reticulum of cardiac muscle cells. The hydrophobic C-terminal 28 amino acid fragment of phospholamban (hPLB) anchors the protein in the membrane and may form part of a Ca(2+)-selective ion channel. We have used polarized attenuated total(More)
The Kura-Araxes cultural tradition existed in the highlands of the South Caucasus from 3500 to 2450 BCE (before the Christian era). This tradition represented an adaptive regime and a symbolically encoded common identity spread over a broad area of patchy mountain environments. By 3000 BCE, groups bearing this identity had migrated southwest across a wide(More)
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