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A S THE PREVALENCE OF OBEsity increases in the United States, 1,2 concern about the association of body weight with excess mortality has also increased. However, estimating deaths attributable to overweight and obesity in the US population raises complex meth-odologic issues. 3,4 In several previous studies, 5-7 relative risk estimates from epidemiologic(More)
CONTEXT The association of body mass index (BMI) with cause-specific mortality has not been reported for the US population. OBJECTIVE To estimate cause-specific excess deaths associated with underweight (BMI <18.5), overweight (BMI 25-<30), and obesity (BMI > or =30). DESIGN, SETTING, AND PARTICIPANTS Cause-specific relative risks of mortality from the(More)
BACKGROUND Red meat and processed meat have been associated with carcinogenesis at several anatomic sites, but no prospective study has examined meat intake in relation to a range of malignancies. We investigated whether red or processed meat intake increases cancer risk at a variety of sites. METHODS AND FINDINGS The National Institutes of Health(More)
BACKGROUND Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown. METHODS We used information on traditional risk factors and 10 common genetic variants associated with breast cancer in 5590 case subjects and 5998 control(More)
BACKGROUND To clarify which types of cancer result from AIDS, we compared the cancer experiences of people with AIDS with those of the general population by matching population-based cancer and AIDS registries in the USA and Puerto Rico. METHODS We used a probabilistic matching algorithm to compare names, birth dates, and, where available, social-security(More)
BACKGROUND Gastric cancer is generally thought to arise through a series of gastric mucosal changes, but the determinants of the precancerous lesions are not well understood. To identify such determinants, we launched a follow-up study in 1989-1990 among 3433 adults in Linqu County, China, a region with very high rates of gastric cancer. METHODS Data on(More)
The attributable risk (AR), defined as AR = [Pr(disease) - Pr(disease/no exposure)]/Pr(disease), measures the proportion of disease risk that is attributable to an exposure. Recently Bruzzi et al. (1985, American Journal of Epidemiology 122, 904-914) presented point estimates of AR based on logistic models for case-control data to allow for confounding(More)
A new method based on the reported incubation period of transfusion-associated AIDS was used to estimate the number of AIDS cases likely to arise in the USA among those infected before 1986. Between 1986 and 1991 102,000 new cases are projected, with a total cumulative incidence of 135,000 AIDS cases. These estimates do not account for new infections after(More)
BACKGROUND Breast, endometrial, and ovarian cancers share some hormonal and epidemiologic risk factors. While several models predict absolute risk of breast cancer, there are few models for ovarian cancer in the general population, and none for endometrial cancer. METHODS AND FINDINGS Using data on white, non-Hispanic women aged 50+ y from two large(More)