Mitchell D. Creinin

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BACKGROUND Misoprostol is increasingly used to treat women who have a failed pregnancy in the first trimester. We assessed the efficacy, safety, and acceptability of this treatment in a large, randomized trial. METHODS A total of 652 women with a first-trimester pregnancy failure (anembryonic gestation, embryonic or fetal death, or incomplete or(More)
BACKGROUND Tenofovir (TFV) gel is being evaluated as a microbicide with pericoital and daily regimens. To inhibit viral replication locally, an adequate concentration in the genital tract is critical. METHODS AND FINDINGS Forty-nine participants entered a two-phase study: single-dose (SD) and multi-dose (MD), were randomized to collection of genital tract(More)
We performed a retrospective analysis to ascertain how accurately women who believe that they have regular menstrual cycles estimate the length of their actual cycles. Data were extracted from a chart review of subjects from three different studies of barrier contraceptives. Subjects were between 18 and 40 years of age and reported "regular" prestudy(More)
OBJECTIVE The purpose of this study was to estimate whether the efficacy of treatment with intravaginal misoprostol for first-trimester pregnancy failure is enhanced by the addition of saline solution. STUDY DESIGN Eighty women with embryonic/fetal death or anembryonic pregnancy were assigned randomly to receive either 800 microg of misoprostol with(More)
OBJECTIVE To assess 3-year data on the efficacy and safety of a new 52-mg levonorgestrel intrauterine contraceptive (LNG20) designed for up to 7 years use. STUDY DESIGN Nulliparous and parous women aged 16-45 years at enrollment with regular menstrual cycles and requesting contraception were enrolled in an open-label, partially randomized trial to(More)
BACKGROUND This study was conducted to assess the feasibility of using telephone calls combined with high-sensitivity urine pregnancy testing as a primary method of follow-up after medical abortion. METHODS We enrolled 139 women up to 63 days of gestation to receive mifepristone 200 mg orally and misoprostol 800 mcg vaginally or buccally, per their(More)
OBJECTIVE To review our experience with low-dose IM methotrexate for the medical management of ectopic pregnancy (EP). DESIGN Retrospective chart review. SETTING Magee-Womens Hospital, Pittsburgh, Pennsylvania. PATIENT(S) The first 50 women treated by the resident service in whom EP was diagnosed and treated with methotrexate. INTERVENTION(S)(More)
Medical abortion offers an important alternative to surgical abortion for women with early pregnancies who wish to avoid a surgical procedure. More than 3 million women worldwide have had medical abortions in the past decade alone. The best-studied regimens include mifepristone orally followed 36 to 48 hours later by a prostaglandin analog administered(More)
BACKGROUND Incarcerated women have had limited access to health care prior to their arrest. Although their incarceration presents an opportunity to provide them with health care, their reproductive health needs have been overlooked. STUDY DESIGN We performed a cross-sectional study of a nationally representative sample of 950 correctional health providers(More)