Mitchel Byron Harris

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OBJECTIVE Significant controversy exists regarding the optimal management of thoracolumbar injuries. This is in part due to the lack of understanding of the natural history of various injury subtypes and the absence of a universally accepted classification scheme that facilitates communication among care providers and assists in directing treatment. The(More)
OBJECTIVE AND METHOD Findings from both animal and human research suggest that pain sensitivity changes across the menstrual cycle; however, among humans the nature of these menstrual cycle effects remains unclear. The present study used a repeated-measures design to evaluate changes in thermal and ischemic pain responses during three phases of the(More)
STUDY DESIGN Two-part study. Part One: the analysis of surveys distributed to members of the Orthopaedic Trauma Association (OTA) and 1000 surgeon members of NASS. Part Two: a prospective clinical study evaluating a new algorithm to evaluate the cervical spine in polytrauma patients. OBJECTIVES To determine if there is a consensus of the optimal method(More)
The treatment of acute myeloid leukemia (AML) in children with Down's syndrome (DS) has engendered considerable controversy. Because of the concerns for toxicity and increased rate of infections, treatment approaches varied considerably in the past with mixed results. However, experience on the recently completed Pediatric Oncology Group (POG) 8498 AML(More)
Intramedullary nailing preceded by canal reaming is the current standard of treatment for long-bone fractures requiring stabilization. However, conventional reaming methods can elevate intramedullary temperature and pressure, potentially resulting in necrotic bone, systemic embolism, and pulmonary complications. To address this problem, a reamer irrigator(More)
BACKGROUND CONTEXT Patients with spinal tumors are often referred for preoperative angiography and embolization before surgical resection to minimize intraoperative bleeding. PURPOSE The purpose of the present study was to investigate the angiographic appearance of a variety of spinal tumors, assess the safety and efficacy of preoperative embolization in(More)
STUDY DESIGN Cadavers were dissected anatomically to identify the course of the superior laryngeal nerve relative to the spinal column. OBJECTIVE To illustrate the anatomic relation of the SLN with respect to its vulnerability during anterior cervical spine procedures. SUMMARY OF BACKGROUND DATA There is ample literature referencing the superior(More)
BACKGROUND CONTEXT The epidemiology of cervical spine fractures and associated spinal cord injury (SCI) has not previously been estimated within the American population. PURPOSE To determine the incidence of cervical spine fractures and associated SCI and identify potential risk factors for these injuries in a large multicultural military population. (More)
BACKGROUND Contemporary understanding of the biomechanics, natural history, and methods of treating thoracolumbar spine injuries continues to evolve. Current classification schemes of these injuries, however, can be either too simplified or overly complex for clinical use. METHODS The Spine Trauma Group was given a survey to identify similarities in(More)
PURPOSE To determine the response rate of the combination of cyclophosphamide and topotecan in pediatric patients with recurrent or refractory malignant solid tumors. PATIENTS AND METHODS A total of 91 pediatric patients, 83 of whom were fully assessable for response and toxicity, received cyclophosphamide (250 mg/m2/dose) followed by topotecan (0.75(More)