Mistuomi Hirashima

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Galectin-9 (Gal-9) is a β-galactoside-binding protein involved in various biologic processes, including cell aggregation, adhesion, chemoattraction, and apoptosis. Little is known, however, about the regulation mechanisms of Gal-9 production. Recent studies reported high plasma Gal-9 levels in humans infected with human immunodeficiency virus-1 and dengue(More)
BACKGROUND Galectin-9 (Gal-9) is a member of the galectin family of lectins that exhibit binding affinity for β-galactosides. We found a T cell line-derived Gal-9 with novel eosinophil chemoattractant activity, but its role in eosinophilic inflammation of the lung is unknown. We evaluated the role of Gal-9 in Ascaris suum-induced eosinophilic lung(More)
BACKGROUND Viral respiratory infection is the most common cause of acute asthma exacerbation in patients with stable asthma. The replication of most respiratory viruses requires the generation of double-stranded RNA (dsRNA), resulting in the activation of host immune responses. Synthetic dsRNA, polyinosinic-polycytidylic acid (PolyIC), mimics the effects of(More)
The effect of IL-4 on antigen-induced production of eosinophil chemotactic factors (ECF) from human peripheral blood mononuclear cells (PBMC) was examined. Antigen-induced ECF production was enhanced in a dose-dependent manner when PBMC were pretreated with IL-4. The most potent enhancement was induced by IL-4 at a concentration of 30 U in(More)
The chemotactic response of eosinophils from 16 patients with atopic dermatitis (AD) to 5 eosinophil chemotactic factors (ECFs) were examined to clarify whether the response is associated with the clinical severity of AD. The factors included ECF-P15, -P16, -P17, -P18 and -P19 and were derived from a T cell line, STO-2. The patients were divided into 2(More)
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