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The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported(More)
OBJECTIVE To determine the clinical spectrum of rickets among black children admitted to King Edward VIII Hospital, Durban. DESIGN Prospective study of black children with rickets beyond infancy. SETTING Hospital-based population; King Edward VIII Hospital, Durban. PARTICIPANTS A total of 37 patients, aged 1-12 years, were recruited over a 3-year(More)
BACKGROUND Antibiotic consumption is a major driver of bacterial resistance. To address the increasing burden of multi-drug resistant bacterial infections, antibiotic stewardship programmes are promoted worldwide to rationalize antibiotic prescribing and conserve remaining antibiotics. Few studies have been reported from developing countries and none from(More)
Bacterial meningitis remains the most common type of central nervous system infection in both developing and developed countries. Despite modern antimicrobial chemotherapy, the incidence of severe neurological sequelae remains high. We review the pathogenesis of these sequelae and correlate them with computed tomography (CT) appearances. Early diagnosis and(More)