Misato Kikuchi

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OBJECT Ultraviolet (UV) light irradiation can lead to immunomodulation. The purpose of this study was to determine the preventive effect of UV light on cerebral vasospasm by using a rabbit common carotid artery (CCA) model. METHODS Rabbit CCAs were constricted for a long period by application of autologous blood within a silicon sheath. Before immersion(More)
The effect of melatonin on the number of synaptic ribbons (SR) in the pineal photoreceptor cells was examined in the Japanese newt using electron microscopy. Under a light-dark cycle of LD 12:12 (lights on at 07:00), a subcutaneous injection of 10 microg of melatonin at two times during the day (at 11:00 and 11:30) did not increase the number of SR.(More)
Adult T cell leukemia/lymphoma (ATL) is a highly aggressive malignancy of T cells caused by human T cell lymphotropic virus type 1 (HTLV-1). Recent clinical studies have suggested that allogeneic stem cell transplantation (HSCT) improves the clinical course of ATL by harnessing a graft-versus-ATL effect, and that donor-derived HTLV-1 Tax-specific CD8+(More)
BACKGROUND Preemptive therapy with ganciclovir (GCV) based on the results of a cytomegalovirus (CMV) antigenemia assay is a standard strategy for preventing CMV disease after allogeneic hematopoietic cell transplantation (HCT). However, the appropriate threshold of antigenemia-positive cells for deciding when to start GCV remains unclear. PATIENTS This(More)
The circadian locomotor activity rhythm of the Japanese newt has been thought to be driven by a putative brain oscillator(s) subordinate to the pineal clock. The existence of mutual coupling between the pineal clock and the brain oscillator(s) in vivo was examined. We covered the newt's skull with aluminum foil and simultaneously reversed the light-dark(More)
OBJECTIVE Chronic cerebral vasospasm is resistant to conventional treatments despite recent advances in treatment modalities. We studied the preventive effect of ultraviolet (UV) irradiation on development of vasospasm and its mechanism in a rat femoral artery model. METHODS The rat femoral artery model for vasospasm was used in this investigation (n =(More)
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