Miruna Negulescu

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Osteochondroma are the bone tumors most frequently found in adolescents or young adults. Most often discovered by accidental findings, they however may be diagnosed while some complications. They are commonly described as solitary findings while multiple exostoses are rather included in an inherited disease. We report the rare case of a 24-year-old patient(More)
Vandetanib therapy is a novel once-daily oral multitargeted tyrosine kinase inhibitor, which is currently used in advanced or metastatic medullary thyroid cancer. Skin toxicities are among the most prevalent adverse events reported with this targeted therapy (e.g. acne-like rash, hand-foot skin reaction, hair changes, and paronychia). In addition,(More)
The combination of MEK inhibitor (cobimetinib, trametinib) and BRAF inhibitor (vemurafenib, dabrafenib) is now the first-line treatment in patients with BRAF V600-mutated metastatic melanoma. This association reduces cutaneous adverse events induced by BRAF inhibitors alone, including photosensitivity, hand-foot syndrome, hyperkeratosis, alopecia, skin(More)
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