Mirta Roses

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Female relatives of 41 Duchenne muscular dystrophy proband cases were studied with a panel of carrier-detection tests. A total of 277 relatives were tested in order to determine which mothers had affected sons as a result of new mutation. In 39 of 41 pedigrees the data demonstrate that a mutation cannot be postulated; the 2 megative pedigrees were(More)
Thirty mothers of patients with Duchenne muscular dystrophy were studied with serum enzyme tests, including serum glutamic-oxaloacetic transminase, creatine kinase, and lactate dehydrogenase isoenzymes. In addition, females from the mothers' pedigrees were studied. Lactate dehydrogenase isoenzyme 5 determinations were as senitive an indicator of carrier(More)
A very large segment of the world's population is without a microbiologically safe water supply. It is estimated that in Latin America more than 40% of the population is utilizing water of dubious quality for human consumption. This figure is probably even higher in Africa and areas of southeast Asia. Water used for drinking and food preparation can be an(More)
Surely no disease group is as vast and complex in scope as the noncommunicable diseases (NCDs). Incorporating social determinants ranging from population growth, aging, globalization, and urbanization to income and education, and risk factors including tobacco, alcohol, diet, and physical activity, the NCDs call for an equally massive and comprehensive(More)
1 Universidade Estadual do Norte do Paraná, Bandeirantes, Brasil. 2 Escola Paulista de Enfermagem, Universidade Federal de São Paulo, São Paulo, Brasil. 3 Setor Estadual de Educação e Gênero, Movimento dos Trabalhadores Rurais Sem Terra, Curitiba, Brasil. 4 Grupo de Investigación de Salud Pública, Universidad de Alicante, CIBERESP, Alicante, España. 5(More)
The application of recombinant DNA techniques applied to the study of genetic neurological diseases will play a major role in the practice of neurology in upcoming years. Strategies are now available to develop useful and relatively simple biochemical diagnostic tests for heterozygous individuals with diseases inherited as autosomal dominant traits. In(More)
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