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Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis

• Miroslav Var̆echa, Michaela Potěšilová, Pavel Matula, Michal Kozubek
• Molecular and Cellular Biochemistry
• 2011

Apoptosis is a natural form of cell death involved in many physiological changes in the cell. Defects in the process of apoptosis can lead to serious diseases. During some apoptotic pathways,… (More)

Transport function and regulation of mitochondrial uncoupling proteins 2 and 3.

• Martin Jabůrek, Miroslav Var̆echa, +6 authors Keith D. Garlid
• The Journal of biological chemistry
• 1999

Uncoupling protein 1 (UCP1) dissipates energy and generates heat by catalyzing back-flux of protons into the mitochondrial matrix, probably by a fatty acid cycling mechanism. If the newly discovered… (More)

Prediction of localization and interactions of apoptotic proteins

• Miroslav Var̆echa, Michal Zimmermann, Jana Amrichová, Vladimír Ulman, Pavel Matula, Michal Kozubek
• Journal of Biomedical Science
• 2009

During apoptosis several mitochondrial proteins are released. Some of them participate in caspase-independent nuclear DNA degradation, especially apoptosis-inducing factor (AIF) and endonuclease G… (More)

How do uncoupling proteins uncouple?

• Keith D. Garlid, Martin Jabůrek, Pavel Jezek, Miroslav Var̆echa
• Biochimica et biophysica acta
• 2000

According to the proton buffering model, introduced by Klingenberg, UCP1 conducts protons through a hydrophilic pathway lined with fatty acid head groups that buffer the protons as they move across… (More)

An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.

• S Paige Taylor, Michaela Kunova Bosakova, +17 authors Pavel Krejcí
• Human molecular genetics
• 2016

The short rib polydactyly syndromes (SRPS) are a group of recessively inherited, perinatal-lethal skeletal disorders primarily characterized by short ribs, shortened long bones, varying types of… (More)

SUV39h- and A-type lamin-dependent telomere nuclear rearrangement.

• Radka Uhlířová, Andrea Harničarová Horáková, +8 authors Eva Bártová
• Journal of cellular biochemistry
• 2010

Telomeres are specialized chromatin structures that are situated at the end of linear chromosomes and play an important role in cell senescence and immortalization. Here, we investigated whether… (More)

Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells

• Miroslav Var̆echa, Jana Amrichová, Michal Zimmermann, Vladimír Ulman, Emílie Lukášová, Michal Kozubek
• Apoptosis
• 2007

We studied the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID in silico using three prediction tools and in living cells using both single-cell colocalization image… (More)

ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1,…

• Lukas Balek, Iva Gudernová, +10 authors Pavel Krejcí
• Bone
• 2017

Tyrosine kinase inhibitors are being developed for therapy of malignancies caused by oncogenic FGFR signaling but little is known about their effect in congenital chondrodysplasias or… (More)

Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage.

• Marcela Buchtová, Veronika Oralová, +19 authors Pavel Krejcí
• Biochimica et biophysica acta
• 2015

Aberrant fibroblast growth factor (FGF) signaling disturbs chondrocyte differentiation in skeletal dysplasia, but the mechanisms underlying this process remain unclear. Recently, FGF was found to… (More)

Alkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H(+) translocation by UCP1 is not necessary for uncoupling.

• Martin Jabůrek, Miroslav Var̆echa, Pavel Jezek, Keith D. Garlid
• The Journal of biological chemistry
• 2001

The mechanism of fatty acid-dependent uncoupling by mitochondrial uncoupling proteins (UCP) is still in debate. We have hypothesized that the anionic fatty acid head group is translocated by UCP, and… (More)

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