Miroslav Hájek

Iva Pichová2
Olga Hrušková-Heidingsfeldová1
Václava Bauerová1
Karolína Strohalmová1
2Iva Pichová
1Olga Hrušková-Heidingsfeldová
1Václava Bauerová
1Karolína Strohalmová
1Ivana Křížová
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  • Michaela Rumlová, Ivana Křížová, Alena Keprová, Romana Hadravová, Michal Doležal, Karolína Strohalmová +3 others
  • 2014
Apoptosis is one of the presumptive causes of CD4+ T cell depletion during HIV infection and progression to AIDS. However, the precise role of HIV-1 in this process remains unexplained. HIV-1 protease (PR) has been suggested as a possible factor, but a direct link between HIV-1 PR enzymatic activity and apoptosis has not been established. Here, we show that(More)
Vacuolar hydrolases have been thoroughly characterized in Saccharomyces cerevisiae, but their homologues in the fungal pathogen Candida albicans have received less attention. The genes APR1 and CPY1 of C. albicans encode putative vacuolar aspartic proteinase and serine carboxypeptidase, respectively. We examined properties of apr1Δ and cpy1Δ mutants,(More)
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