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This study presents a model of chronic, recurrent, spontaneous seizures in the intact isolated hippocampal preparation from mice aged P8-P25. Field activity from the CA1 pyramidal cell layer was recorded and recurrent, spontaneous seizure-like events (SLEs) were observed in the presence of low Mg2+ (0.25 mM) artificial cerebrospinal fluid (ACSF). Hippocampi(More)
In this paper, we investigate the dynamical scenarios of transitions between normal and paroxysmal state in epilepsy. We assume that some epileptic neural network are bistable i.e., they feature two operational states, ictal and interictal that co-exist. The transitions between these two states may occur according to a Poisson process, a random walk process(More)
A 3D microsystem for multi-site penetrating extracellular neural recording from the brain is presented. A 16×16-channel neural recording interface integrated prototype fabricated in 0.35µm CMOS occupies 3.5mm×4.5mm area. Each recording channel dissipates 15µW of power with input-referred noise of 7µV rms over 5kHz bandwidth. A switched-capacitor delta(More)
It has been previously shown that wavelet artificial neural networks (WANNs) are able to classify the different states of epileptiform activity and predict the onsets of seizure-like events (SLEs) by offline processing (Ann. Biomed. Eng. 33(6):798-810, 2005) of the electrical data from the in-vitro hippocampal slice model of recurrent spontaneous SLEs. The(More)
Localizing the seizure focus is difficult and frequently, multiple sites are found. This reflects our poor understanding of the fundamental mechanisms of seizure generation and propagation. We used multisite electrophysiological recordings in two seizure models and voltage-sensitive dye imaging, to spatiotemporally characterize the initiation and(More)
BACKGROUND High-dose opioid therapy can precipitate seizures; however, the mechanism of such a dangerous adverse effect remains poorly understood. The aim of our study was to determine whether the neuroexcitatory activity of high-dose morphine is mediated by selective stimulation of opioid receptors. METHODS Mice hippocampi were resected intact and bathed(More)
A 256-channel integrated interface for simultaneous recording of distributed neural activity from acute brain slices is presented. An array of 16 times 16 Au recording electrodes are fabricated directly on the die. Each channel implements differential voltage acquisition, amplification and band-pass filtering. In-channel analog memory stores an electronic(More)
We present a neural recording and spectral analysis RECORDING ANALYSIS integrated microsystem. It is the instrumentational and computa-INTERACE PROCESSOR tional core of an envisioned miniature implantable brain implant for automated epileptic seizure therapy. The microsystem com-WAVELET bines two functional blocks: the neural recording interface and(More)
— The architecture and VLSI implementation of an epileptic seizure prediction microsystem are presented. The microsystem comprises a neural recording interface and a seizure prediction processor. The two functional blocks have been proto-typed in a 0.35 µm CMOS technology and experimentally characterized. The integrated microsystem is validated in(More)