Mirna Marcela Biglione

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In Argentina, current procedures to ensure the safety of the blood supply for transfusion include the serologic detection of specific blood-borne infections. The aim of this study was to evaluate the prevalence and the genetic diversity of hepatitis B virus (HBV) and hepatitis D virus (HDV) in blood donor populations from two distantly located Argentine(More)
Although the detection of HTLV antibodies became mandatory in Argentinean blood banks since 2005, there is no recommendation on how to perform the screening. As a consequence, there is a variable number of HTLV false positives depending on the kit used. The aim of the present study was to evaluate the performance of six commercial screening tests available(More)
Are seroindeterminate western blot patterns in human T-Cell lymphotropic virus type 1 (Htlv-1) infected individuals associated with low proviral load levels? For HTLV-1/2 diagnosis, reactive screening results are generally confirmed by Western Blot (WB). However, the large number of indeterminate WB patterns is still a problem worldwide. The aim of this(More)
BACKGROUND indeterminate Western blot (WB) patterns are a major concern for diagnosis of human T-cell lymphotropic virus type 1 (HTLV-1) infection, even in non-endemic areas. OBJECTIVES (a) to define the prevalence of indeterminate WB among different populations from Argentina; (b) to evaluate if low proviral load (PVL) is associated with indeterminate WB(More)
HTLV-1 infects about 20 million people worldwide and is considered the etiologic agent of Adult T-cell Leukemia/ Lymphoma (ATLL) and HTLV-1 Associated Mielopathy/ Tropical Spastic Paraparesis (HAM/TSP). There is still no effective therapy for none of the pathologies. Porcine cere-bral cortex GM1 monosialoganglioside (SINAXIAL ®) is being prescribed for(More)
HTLV-1 is the etiologic agent of Adult T-cell Leukemia/ Lymphoma (ATLL) and HTLV-1 Associated Mielopathy/ Tropical Spastic Paraparesis (HAM/TSP). Tax, a critical viral factor for genomic activation and viral gene expression , has been implied in cell transformation. The aim of this study was to analyze the presence of nucleotide poly-morphisms in the tax(More)
Hepatitis B virus (HBV) is a worldwide public health concern. The circulation of strains carrying mutations in the viral proteins implies both clinical and therapeutics challenges. HBV complete genomes (HBV-CGs) were reported from injecting drug users and HBV chronically infected patients from Argentina—including Amerindians—although no studies were(More)