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BACKGROUND & AIMS In food allergic individuals, exposure to food allergens by the oral route can trigger immediate (within minutes) local hypersensitivity reactions in the intestine followed by a late-phase inflammatory response. Previous work has shown that CD23 is constitutively expressed by human intestinal epithelial cells and mediates the uptake of(More)
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder associated with allergic hypersensitivity to food. We interrogated >1.5 million genetic variants in EoE cases of European ancestry and subsequently in a multi-site cohort with local and out-of-study control subjects. In addition to replicating association of the 5q22 locus (meta-analysis(More)
OBJECTIVES Eosinophilic esophagitis (EoE) is a chronic inflammatory condition that causes esophageal remodeling and stricture formation. We compared the clinical course of symptoms, endoscopic findings, histology, and changes in phenotype over time in EoE patients with inflammatory and fibrostenotic phenotypes. METHODS Data were obtained from EoE patients(More)
Eosinophilic esophagitis (EoE) is a chronic immune, antigen-mediated, disease of the esophagus characterized by symptoms related to esophageal dysfunction and significant esophageal eosinophilic infiltration. 1 EoE has been described in many places throughout the World, including North Amer-and the Middle East. There are no reported EoE cohorts in(More)
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