Mirko S. Faber

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BACKGROUND We describe an outbreak of gastroenteritis and the hemolytic-uremic syndrome caused by Shiga-toxin-producing Escherichia coli in Germany in May, June, and July, 2011. The consumption of sprouts was identified as the most likely vehicle of infection. METHODS We analyzed data from reports in Germany of Shiga-toxin-producing E. coli(More)
BACKGROUND A large outbreak of the hemolytic-uremic syndrome caused by Shiga-toxin-producing Escherichia coli O104:H4 occurred in Germany in May 2011. The source of infection was undetermined. METHODS We conducted a matched case-control study and a recipe-based restaurant cohort study, along with environmental, trace-back, and trace-forward(More)
The cytochrome P450 enzyme CYP1A2 mediates the rate-limiting step in the metabolism of many drugs including theophylline, clozapine, and tacrine as well as in the bioactivation of procarcinogens. CYP1A2 activity shows both pronounced intra- and interindividual variability, which is, among other factors, related to smoking causing enzyme induction, to drug(More)
BACKGROUND AND OBJECTIVE Cytochrome P450 (CYP) 1A2 activity is induced by cigarette smoking. Thus smoking cessation in patients while they are undergoing therapy with a CYP1A2 substrate such as theophylline or clozapine increases its concentrations and may cause adverse effects. Our objective was to determine the time course of CYP1A2 activity changes after(More)
Since early May 2011, an increased incidence of haemolytic uraemic syndrome (HUS) and bloody diarrhoea related to infections with Shiga toxin-producing Escherichia coli (STEC) has been observed in Germany, with most cases in the north of the country. Cases reported from other European countries had travelled to this area. First results of a case–control(More)
From January to April 2010, 396 hantavirus infections were notified in Germany, a considerable increase compared with previous years (mean: 83 for January-April 2004-2009) including the record-setting year, 2007 (n=232 January-April). Most patients are residents of known Puumala virus endemic areas in southern Germany. The recent increase in notified(More)
E MacDonald (emily.macdonald@fhi.no)1,2, A Steens1,2, K Stene-Johansen1, S Gillesberg Lassen 3, S E Midgley4, J Lawrence5, J Crofts5, S L Ngui5, K Balogun5, C Frank6, M Faber6, M Gertler6,7, L Verhoef8, M Koopmans8, J Sane2,8, W van Pelt8, L Sundqvist9, L Vold1 1. Norwegian Institute of Public Health, Oslo, Norway 2. European Programme for Intervention(More)
Surveillance and outbreak reports Emergence of carbapenemase-producing Enterobacteriaceae in France, 2004 to 2011 11 by S Vaux, A Carbonne, JM Thiolet, V Jarlier, B Coignard, RAISIN and Expert Laboratories Groups Clusters of infectious diseases in German nursing homes – observations from a prospective infection surveillance study, October 2008 to August(More)
Physicians mention patients' expectations as a reason for prescribing antibiotics for common (viral) upper respiratory tract infections despite clinical evidence against their use and the physicians' better judgement. We aimed to assess the prevalence of such expectations and factors of influence (knowledge and attitudes) in Germany's general population. In(More)