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Animal and human autopsy studies suggest that subfields of the hippocampal formation are differentially affected by neuropsychiatric diseases. Therefore, subfield volumes may be more sensitive to effects of disease processes. The few human studies that segmented subfields of the hippocampal formation in vivo either assessed the subfields only in the body of(More)
BACKGROUND Depression in the elderly was found to be associated with a variety of risk-factors in cross sectional designs. Based on the vulnerability-stress model, etiologic pathways for depression have been suggested, with vulnerability modifying the effect of stress factors. The current prospective study tests an etiologic model for depression incidence,(More)
OBJECTIVES To review studies that have reported on the prevalence of memory complaints and the relationship between memory complaints and impairment or decline (dementia) in elderly individuals. DATA SOURCES AND STUDY SELECTION All publications in the English language relating to memory complaints, memory impairment, cognitive disorder and dementia in(More)
BACKGROUND Increased levels of inflammatory proteins have been found in the brains and plasma samples of patients with dementia. Whether the levels of inflammatory proteins in plasma samples are elevated before clinical onset of dementia is unclear. OBJECTIVE To determine whether high levels of inflammatory proteins in plasma samples are associated with(More)
CONTEXT The recent focus on the development of preventive interventions for Alzheimer disease has fueled the search for biomarkers of presymptomatic disease. Patients with Alzheimer disease and mild cognitive impairment have marked atrophy of the hippocampus and amygdala compared with healthy elderly people. Whether atrophy of these structures is also(More)
BACKGROUND The association between depression and increased mortality risk in older persons may depend on the severity of the depressive disorder and gender. AIMS To investigate the association between major and mild depressive syndromes and excess mortality in community-living elderly men and women. METHOD Depression (Geriatric Mental State AGECAT) was(More)
CONTEXT Strategies for prevention of depression are hindered by lack of evidence about the combined predictive effect of known risk factors. OBJECTIVES To develop a risk algorithm for onset of major depression. DESIGN Cohort of adult general practice attendees followed up at 6 and 12 months. We measured 39 known risk factors to construct a risk model(More)
The 6-year stability of reading performance was investigated in subjects who were normal at baseline but suspect for dementia at follow-up (MMSE score < or = 23; n = 197), and in a cognitively intact control group (n = 117). The Dutch version of the National Adult Reading Test (DART) was used. The DART-based estimate of IQ appeared to be very stable in(More)
OBJECTIVE Missing indicator method (MIM) and complete case analysis (CC) are frequently used to handle missing confounder data. Using empirical data, we demonstrated the degree and direction of bias in the effect estimate when using these methods compared with multiple imputation (MI). STUDY DESIGN AND SETTING From a cohort study, we selected an exposure(More)
We compared hippocampal subfield and entorhinal cortex (ERC) volumes between patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls without cognitive impairment. Additionally, we investigated the relation between age and hippocampal subfields and ERC in controls. We performed ultra-high field 0.7 mm(3) 7Tesla magnetic(More)