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Animal and human autopsy studies suggest that subfields of the hippocampal formation are differentially affected by neuropsychiatric diseases. Therefore, subfield volumes may be more sensitive to effects of disease processes. The few human studies that segmented subfields of the hippocampal formation in vivo either assessed the subfields only in the body of(More)
OBJECTIVES To review studies that have reported on the prevalence of memory complaints and the relationship between memory complaints and impairment or decline (dementia) in elderly individuals. DATA SOURCES AND STUDY SELECTION All publications in the English language relating to memory complaints, memory impairment, cognitive disorder and dementia in(More)
BACKGROUND Depression in the elderly was found to be associated with a variety of risk-factors in cross sectional designs. Based on the vulnerability-stress model, etiologic pathways for depression have been suggested, with vulnerability modifying the effect of stress factors. The current prospective study tests an etiologic model for depression incidence,(More)
This study investigated whether the association between depression and diabetes was influenced by the presence of chronic somatic disease. To distinguish between depression and other psychosocial complaints, we studied the onset of diabetes in antidepressant (AD) users and benzodiazepine (BD) users, respectively. From the PHARMO database, which includes(More)
S EVERAL FINDINGS SUGGEST THAT oxidative stress may play an important role in the pathogen-esis of Alzheimer disease. First, the brains of patients with Alzheimer disease contain lesions that are typically associated with exposure to free radicals. 1,2 In addition, oxidative stress in brains of Alzheimer patients is indicated by elevated cerebral levels of(More)
CONTEXT Strategies for prevention of depression are hindered by lack of evidence about the combined predictive effect of known risk factors. OBJECTIVES To develop a risk algorithm for onset of major depression. DESIGN Cohort of adult general practice attendees followed up at 6 and 12 months. We measured 39 known risk factors to construct a risk model(More)
BACKGROUND Increased levels of inflammatory proteins have been found in the brains and plasma samples of patients with dementia. Whether the levels of inflammatory proteins in plasma samples are elevated before clinical onset of dementia is unclear. OBJECTIVE To determine whether high levels of inflammatory proteins in plasma samples are associated with(More)
BACKGROUND The association between depression and increased mortality risk in older persons may depend on the severity of the depressive disorder and gender. AIMS To investigate the association between major and mild depressive syndromes and excess mortality in community-living elderly men and women. METHOD Depression (Geriatric Mental State AGECAT) was(More)
We compared hippocampal subfield and entorhinal cortex (ERC) volumes between patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls without cognitive impairment. Additionally, we investigated the relation between age and hippocampal subfields and ERC in controls. We performed ultra-high field 0.7 mm(3) 7Tesla magnetic(More)
OBJECTIVE Results of previous studies suggest that memory complaints may predict cognitive decline and dementia among elderly people in whom cognitive impairment is already apparent. However, cognitive decline is often a gradual process, and elderly people may notice that their memory deteriorates before mental status tests are able to detect any change in(More)