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Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD. Expand
A Switch between Antioxidant and Prooxidant Properties of the Phenolic Compounds Myricetin, Morin, 3′,4′-Dihydroxyflavone, Taxifolin and 4-Hydroxy-Coumarin in the Presence of Copper(II) Ions: A
The overall results suggest that the most pronounced DNA damage has been observed for flavonoids containing higher number of hydroxyl groups, such as myricetin, morin and taxifolin in the presence of Cu(II) ions. Expand
Management of oxidative stress and other pathologies in Alzheimer’s disease
The aims of this review are to discuss the current therapies based on the “combination-drugs-multitargets” strategy to target multiple pathologies to block the progression of pathogenesis of AD and to establish the ideal dose to develop effective formulations to preserve bioavailability. Expand
Effect of drying methods on the content of natural pigments and antioxidant capacity in extracts from medicinal plants: a spectroscopic study
Medicinal plants are a significant source of biological active and health protective compounds. Post-harvest treatments can affect, in different ways, the content and biological activity of suchExpand
Redox-cycling and intercalating properties of novel mixed copper(II) complexes with non-steroidal anti-inflammatory drugs tolfenamic, mefenamic and flufenamic acids and phenanthroline functionality:
The fluorescence spectroscopy revealed that albumin may act as a targeted drug delivery vehicle for Cu(II) complexes, and the most promising compound, from the viewpoint of its NSAID biological activity is 3, due to the presence of the three fluorine atoms participating in the formation of weak hydrogen-bonds at the DNA surface. Expand
Novel copper(II) complexes with fenamates and isonicotinamide: structure and properties, and interactions with DNA and serum albumin
Reactions of non-steroidal anti-inflammatory drugs tolfenamic (Htolf), meclofenamic (Hmeclf), mefenamic (Hmef), clonixic (Hclon) and niflumic (Hnif) acids with isonicotinamide (isn) and copper(II)Expand
Structure functionality relationship of flavonoids (myricetin, morin, taxifolin and 3′,4′-dihydroxyflavone). A computational study via the cupric ion probe
Abstract The antioxidant and/or prooxidant properties of flavonoids are strongly dependent on their redox metal chelating capacity as well as on the number and positions of hydroxyl groups. In thisExpand
Dimethyl sulfoxide as a strongly coordinating solvent: 3′,4′-dihydroxyflavone-Cu(II)-DMSO system case study
Abstract Dimethyl sulfoxide (DMSO) is an aprotic organic solvent widely used in laboratory practice due to its ability to dissolve both polar and nonpolar compounds. However, DMSO is also commonlyExpand
Antioxidant vs. Prooxidant Properties of the Flavonoid, Kaempferol, in the Presence of Cu(II) Ions: A ROS-Scavenging Activity, Fenton Reaction and DNA Damage Study
It is proposed that the prooxidant properties of Cu-kaempferol complexes may provide anticancer activity of these substances that involve a disturbed metabolism of redox metals such as copper, for example, Menkes disease, and neurological disorders, including Alzheimer’s disease. Expand
Antimicrobial and antifungal activities of bifunctional cooper(ii) complexes with non-steroidal anti-inflammatory drugs, flufenamic, mefenamic and tolfenamic acids and 1,10-phenanthroline
Abstract Cooper(ii) complexes represent a promising group of compounds with antimicrobial and antifungal properties. In the present work, a series of Cu(ii) complexes containing the non-steroidalExpand