Miriam T Schteingart

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Posterior polymorphous corneal dystrophy (PPCD, also known as PPMD) is a rare disease involving metaplasia and overgrowth of corneal endothelial cells. In patients with PPCD, these cells manifest in an epithelial morphology and gene expression pattern, produce an aberrant basement membrane, and, sometimes, spread over the iris and nearby structures in a way(More)
Urbanization in Mexico has given rise to creation of unauthorized squatter settlements on the peripheries of large cities. Such settlements are estimated to house about 1/2 of the urban population of Mexico. These settlers share a low standard of housing resulting from lack of employment and low income. Very often large households are crowded into(More)
OBJECTIVE To identify coexisting ocular diagnoses in a case series of eyes that developed cystoid macular edema (CME) associated with latanoprost therapy. DESIGN Retrospective observational case series. PARTICIPANTS Seven eyes of seven patients who developed CME possibly associated with latanoprost treatment were studied. INTERVENTION When these(More)
Posterior polymorphous corneal dystrophy (PPCD) is an autosomal dominant disorder characterized by corneal endothelial abnormalities, which can lead to blindness due to loss of corneal transparency and sometimes glaucoma. We mapped a new locus responsible for PPCD in a family in which we excluded the previously reported PPCD locus on 20q11, and the region(More)
Substantial evidence indicates that compartmentalized infiltrates of T lymphocytes are central to the pathogenesis of autoimmune diseases such as rheumatoid arthritis, but the mechanisms by which such cells become activated remain unknown. To define surface components of activation pathways important in the function of these cells, we have generated mAb(More)
PURPOSE To evaluate the clinical history, histopathology, and genetics of posterior polymorphous corneal dystrophy (PPMD) in a woman with a prominent retrocorneal membrane. DESIGN Observational case report and genetic analysis of her family, UM:139. METHODS Records were reviewed from a case and associated family members. The diagnosis of PPMD was based(More)
PURPOSE This report describes a case of multiple myeloma that presented as bilateral eyelid ecchymoses and corneal crystals in the absence of widespread signs of systemic disease. METHODS A 55-year-old man was found to have the sudden appearance of bilateral eyelid ecchymoses after he flexed 90 degrees at the waist. On examination, amyloid deposition was(More)