Miriam Merzel Schachter

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Eukaryotic cell division is controlled by cyclin-dependent kinases (CDKs), which require phosphorylation by a CDK-activating kinase (CAK) for full activity. Chemical genetics uncovered requirements for the metazoan CAK Cdk7 in determining cyclin specificity and activation order of Cdk2 and Cdk1 during S and G2 phases. It was unknown if Cdk7 also activates(More)
www.landesbioscience.com Cell Cycle 3239 The cyclin-dependent kinases (CDKs) that control cell division require activation (T) loop phosphorylation for full activity. In metazoans, the only known CDKactivating kinase (CAK) is the Cdk7 complex, which was discovered ~20 y ago and subsequently implicated in CDK activation in vivo in flies and worms. Cdk7 has(More)
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