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Melanocyte transformation associated with substrate adhesion impediment.

• Sueli Mieko Oba-Shinjo, Mariangela Correa, +8 authors Miriam Galvonas Jasiulionis
• Neoplasia
• 2006

Exclude experimental models of malignant transformation employ chemical and physical carcinogens or genetic manipulations to study tumor progression. In this work, different melanoma cell lines were… (More)

Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation.

• Ana Carolina C. Campos, Fernanda Molognoni, +5 authors Miriam Galvonas Jasiulionis
• Neoplasia
• 2007

Both oxidative/nitrosative stress and alterations in DNA methylation are observed during carcinogenesis of different tumor types, but no clear correlation between these events has been demonstrated… (More)

Epigenetic reprogramming as a key contributor to melanocyte malignant transformation.

• Fernanda Molognoni, Adriana T Cruz, +9 authors Miriam Galvonas Jasiulionis
• Epigenetics
• 2011

Melanoma progression requires deregulation of gene expression by currently uncharacterized epigenetic mechanisms. A mouse model based on changes in cell microenvironment was developed by our group to… (More)

Transient inflammatory response induced by apoptotic cells is an important mediator of melanoma cell engraftment and growth.

• Mariangela Correa, Joel Machado, +5 authors Miriam Galvonas Jasiulionis
• International journal of cancer
• 2005

Two murine melanoma cell lines, Tm1 and Tm5, were derived from a nontumorigenic lineage of pigmented murine melanocytes, melan-a. Both Tm1 and Tm5 are invariably tumorigenic in syngeneic mice when… (More)

Tissue inhibitor of metalloproteinase 1 expression associated with gene demethylation confers anoikis resistance in early phases of melanocyte malignant transformation.

• Tatiana Iervolino Ricca, Gangning Liang, Ana Paula M Suenaga, Sang Won Han, Peter A. Jones, Miriam Galvonas Jasiulionis
• Translational oncology
• 2009

Although anoikis resistance has been considered a hallmark of malignant phenotype, the causal relation between neoplastic transformation and anchorage-independent growth remains undefined. We… (More)

Stage-specific glycosphingolipids from amastigote forms of Leishmania (L.) amazonensis. Immunogenicity and role in parasite binding and invasion of macrophages.

• Anita Hilda Straus, Steven B. Levery, +5 authors Helio Kiyoshi Takahashi
• The Journal of biological chemistry
• 1993

Neutral glycosphingolipids (GSLs) from amastigote forms of Leishmania (L.) amazonensis were isolated, and their structures and biological properties were characterized. Based on various… (More)

Endothelial nitric oxide synthase uncoupling as a key mediator of melanocyte malignant transformation associated with sustained stress conditions.

• Fabiana H. M. Melo, Fernanda Molognoni, +5 authors Miriam Galvonas Jasiulionis
• Free radical biology & medicine
• 2011

Melanoma cell lines and cells corresponding to premalignant melanocytes were established by our group after subjecting a nontumorigenic murine melanocyte lineage, melan-a, to sequential cycles of… (More)

Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation

• Mariana Toricelli, Fabiana H. M. Melo, Giovani Bravin Peres, Débora Castanheira Pereira da Silva, Miriam Galvonas Jasiulionis
• Molecular Cancer
• 2012

Anoikis resistance is one of the abilities acquired along tumor progression. This characteristic is associated with metastasis development, since tumorigenic cells must survive independently of… (More)

Apoptotic Cells Contribute to Melanoma Progression and This Effect is Partially Mediated by the Platelet-Activating Factor Receptor

• Andre Luis Lacerda Bachi, Lívia Caires dos Santos, Suely Nonogaki, Sonia Jancar, Miriam Galvonas Jasiulionis
• Mediators of inflammation
• 2012

There is evidence that the platelet-activating factor receptor (PAFR) is involved in the clearance of apoptotic cells by macrophages, and that this is associated with anti-inflammatory phenotype. Our… (More)

Structural and inhibitory properties of a plant proteinase inhibitor containing the RGD motif.

• Adriana Miti Nakahata, Norlene R Bueno, +8 authors Maria Luiza Vilela Oliva
• International journal of biological…
• 2006

Purified from Bauhinia rufa seeds, BrTI is a Kunitz proteinase inhibitor that contains the RGD sequence. BrTI inhibits trypsin (K(iapp) 2.9 nM) and human plasma kallikrein (K(iapp) 14.0 nM) but not… (More)

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