Miriam Elisabeth Uhl

Learn More
The class III histone deacetylase (HDAC) SIRT1 plays a role in the metabolism, aging, and carcinogenesis of organisms and regulates senescence and apoptosis in cells. Recent reports revealed that SIRT1 also deacetylates several DNA double-strand break (DSB) repair proteins. However, its exact functions in DNA repair remained elusive. Using nuclear foci(More)
Resistance towards cytotoxic drugs is one of the primary causes for therapeutic failure in cancer therapy. DNA-repair mechanisms as well as deficient caspases activation play a critical role in apoptosis-resistance of tumor cells towards anticancer drug treatment. Here, we discovered that deficient caspases activation in apoptosis-resistant cancer cells(More)
BACKGROUND Both central sensitization after peripheral tissue injury and the development of opioid tolerance involve activation of N-methyl-D-aspartate (NMDA) receptors. At subanesthetic doses the NMDA receptor antagonist xenon suppresses pain-evoked sensitization of pain-processing areas in the central nervous system. Although numerous studies describe the(More)
Resistance toward cytotoxic drugs is one of the primary causes for therapeutic failure in cancer therapy. DNA repair mechanisms as well as deficient caspases activation play a critical role in apoptosis resistance of tumor cells toward anticancer drug treatment. Here, we discovered that deficient caspases activation in apoptosis-resistant cancer cells(More)
  • 1